PROTEOSTAT® Aggresome Detection Kit is a robust, quantitative detection of aggresomes relevant to the study of neurodegenerative disease, liver disease and toxicology.

• Fixed-cell assay is optimised for antibody co-localisation studies
• Easily quantifies aggresome and related inclusion bodies by flow cytometry
• Useful for the study of neurodegenerative diseases, liver disease, toxicology studies and much more
• Reliable and simple assay doesn’t require non-physiological protein mutations or genetically engineered cell lines
• Validated under a wide range of conditions and with small molecule modulators demonstrating suitability for screening compounds of potential therapeutic value

The PROTEOSTAT® Aggresome Detection Kit is potentially applicable to the identification of small molecules that inhibit aggresome formation as well as immuno-localisation studies between aggregated protein cargo and the various proteins implicated in aggresome formation, such as histone deacetylase 6, parkin, ataxin-3, dynein motor complex and ubiquilin-1.