You searched for: Proteins and Peptides

Supplier: ENZO LIFE SCIENCES

Produced in a baculovirus expression system. The deltaPH domain of human Akt2 (PKBß, Protein Kinase B beta) (aa 119-481) is fused at the N-terminus to a GST-tag.

Supplier: ENZO LIFE SCIENCES

Produced in Sf9 cells. Human VEGFR2 (aa 805-1356).

Supplier: ENZO LIFE SCIENCES

Produced in E. coli. Human 14-3-3σ is fused at the N-terminus to a GST-tag.

Supplier: ENZO LIFE SCIENCES

Potent neurotoxin. Small conductance Cl⁻ channel blocker. Highly specific marker for glioma cells and tumors of neuroectodermal origin. Inhibits the activity of matrix metalloproteinase-2 (MMP-2).

Supplier: ENZO LIFE SCIENCES

Produced in HEK 293 cells. The extracellular domain of human TNF-R2 (aa 1-257) is fused to the Fc portion of human IgG1.

Supplier: ENZO LIFE SCIENCES

Selective cell permeable inhibitor of PKCzeta. Activates eNOS (NOS III) through Akt phosphorylation and can be considered as a nitric oxide production activator in endothelial cells.

Supplier: ENZO LIFE SCIENCES

Isolated from bovine brain. Calmodulin conjugated to 4% cross-linked agarose beads via a 5 atom hydrophilic spacer arm.

Supplier: ENZO LIFE SCIENCES

Produced in HEK 293 cells. The extracellular domain of dectin-2 (aa 44-209) is fused at the N-terminus to the Fc portion of human IgG1.

Supplier: ENZO LIFE SCIENCES

Produced in HEK 293 cells. The extracellular domain of mouse Thy-1 (aa 20-131) is fused to the Fc portion of human IgG1.

Supplier: ENZO LIFE SCIENCES

Produced in E. coli. Active Matrix Metalloproteinase-3 (MMP-3, stromelysin-1, transin) catalytic domain from human cDNA.

Supplier: ENZO LIFE SCIENCES

NEDD8-AMC is a fluorogenic substrate for deNEDDylating enzymes, including NEDP1 and UCH-L3. It is a particularly useful reagent for the study of deNEDDylating activity where detection sensitivity or continuous monitoring of activity is essential.

Supplier: TCI

Melting point: 158 °C
Specific rotation [a]20/D: –7° (C=5, H₂O)
Water: Max. 8,0%
Purity (nonaqueous titration): Min. 98,0% (calculated on anhydrous substance)

Supplier: ENZO LIFE SCIENCES

Linear polyubiquitin chains are useful tools for investigating, amongst other things, the specificity and reactivity of deubiquitinylating enzymes (DUBs) and the recognition and interaction of linear polyubiquitin modified proteins with by ubiquitin binding domain (UBDs) containing proteins.

Supplier: ENZO LIFE SCIENCES

Isolated from mouse submaxillary glands by a modification of the procedure described by T. Darling, et al.; Cell Culture Meth. Mol. Cell Biol. 4, 79 (1984).

Supplier: ENZO LIFE SCIENCES

Produced in HEK 293 cells. The extracellular domain of human TRAIL-R2 (DR5) (aa 52-212) is fused to the Fc portion of human IgG1.

Supplier: ENZO LIFE SCIENCES

ELISAFunctional Application: Stimulates the proliferation of mouse B cells and dendritic cells. The activity of CD40L increases 1'000-fold (stimulation in the ng/ml range) in the presence of the cross-linking enhancer (Prod. No. ALX-804-034).

Supplier: ENZO LIFE SCIENCES

Type I ribosome inactivating protein (RIP). Depurinates RNA in ribosomes, thus inhibiting protein synthesis in eukaryotic cells, which results in cell death. Widely used to construct immunotoxins composed of cell-targeted antibodies. As a type I RIP it lacks the lectin subunit and is practically non-toxic to intact cells.

Supplier: ENZO LIFE SCIENCES

Produced in HEK 293 cells. Human EBI3 (aa 21-229) linked to human IL-12A (aa 23-219) via the linker GGGSGGGSGGGSGGGS is fused at the C-terminus to the Fc portion of human IgG1 and a FLAG®-tag.

Supplier: Shenandoah Biotechnology

IL-7 promotes the stimulation of multipotent (pluripotent) hematopoietic stem cells into lymphoid progenitor cells. IL-7, along with IL-2, 15, and 21, is a member of the common gamma (γc) chain cytokine family.

Supplier: OriGene

Purified recombinant protein of S. pyogenes Cas9 endonuclease (Cas9) containing Simian virus 40 (SV40) T antigen nuclear localisation sequence (NLS) on the N- and C- termini of the protein., with N-terminal HIS tag, expressed in E.coli, sterile-filtered, suitable for cell culture.

Supplier: ENZO LIFE SCIENCES

Produced in HEK 293 cells. The extracellular domain of mouse Thy-1 (aa 20-131) is fused to the Fc portion of human IgG1. The integrin binding sequence RLD of mouse Thy-1 has been changed to RLE abolishing the binding of integrins.

Supplier: ENZO LIFE SCIENCES

The deacetylated state of lysine-16 of histone H4 (H4-K16) is thought to be a critical factor in determining regions of chromatin silencing. Conversely, acetylation of lysine-16 can be associated with increased transcription, such as that due to dosage compensation from the X-chromosome of male Drosophila.

Supplier: ENZO LIFE SCIENCES

Potent, reversible proteasome inhibitor. Specifically inhibits the chymotrypsin-like activity of the proteasome. Has been shown to induce apoptosis in Rat-1 and PC12 cells via a p53-dependent pathway.The ubiquitin-proteasome system (UPS) and autophagy serve as two complementary, reciprocally regulated protein degradation systems, thus blockade of UPS by MG-115 activates autophagy.

Supplier: ENZO LIFE SCIENCES

Wnt expression and signal transduction have been identified as critical components in regulating embryogenesis, cell proliferation, and bone, glucose and lipid metabolism. Wnt-3a signalling also plays a role in regulating the differentation of stem cells. Wnt-3a is a member of the highly conserved, structurally related cysteine-rich Wnt family glycoproteins important for normal developmental processes and oncogenesis.

Supplier: ENZO LIFE SCIENCES

Sensitive fluorogenic substrate for TACE (TNFalpha converting enzyme, ADAM17). Also cleaved by ADAM10 and likely other ADAMs and MMPs. The kcat/Km of TACE for this substrate is 7-fold higher than for the same peptide with the Mca-Dpa fluorophore-quencher pair. FAM fluorescence is quenched by the TAMRA group until cleavage separates them. Ex.: 485 nm, Em.: 535 nm, although the following Ex/Em can also be used: 490,494/515,520 nm. This substrate is useful for inhibitor screening, kinetic analysis, and cellular activity assay.

Supplier: Shenandoah Biotechnology

Fms-related tyrosine kinase 3 ligand (FLT-3 ligand) is a growth factor that regulates hematopoietic cell proliferation. FLT-3 ligand signaling is transmitted through the fms-related tyrosine kinase 3 (FLT-3) receptor. FLT-3 ligand promotes the long-term expansion and differentiation of pro-B cells in the presence of interleukin 7 (IL-7) or in combination of IL-7 and interleukin 3 (IL-3).

Supplier: ProSci Inc.

Superoxide Dismutase (SOD2) belongs to the iron/manganese superoxide dismutase family. SOD2 is a mitochondrial matrix protein that forms a homotetramer and binds one manganese ion per subunit. SOD2 transforms toxic superoxide, a byproduct of the mitochondrial electron transport chain into hydrogen peroxide and diatomic oxygen. It is reported that oxidative stress plays an essential role in the development of breast cancer, while SOD2 is one of the primary enzymes that directly convert potential harmful oxidizing species to harmless metabolites.

Supplier: Biowest

Bovine serum albumin (BSA) is commonly used in cell culture protocols, particularly where protein supplementation is necessary and the other components of serum are unwanted. In cell culture, its main role is as a carrier of small molecules. Because of its negative charge, BSA binds water, salts, fatty acids, vitamins and hormones, then carries these bound components between tissues and cells. The binding capacity also makes BSA an effective scavenger to remove toxic substances, including pyrogens, from the medium.

Supplier: Shenandoah Biotechnology

Cytokines for polarizing mouse T cells into Th9 cells. Th9 cells are a unique subset of T helper cells that produce IL-9. Although the exact function of IL-9 producing T cells is yet to be completely clear it is proposed that these cells could be important in inflammation and helminth infections. Th9 cells can be generated from naive CD4+ T cells in culture by culturing them in the presence of IL-4 and TGF-β 1. It also appears that IFNγ and IL-27 can inhibit the generation of Th9 cells.

Supplier: ProSci Inc.

Neuraminidase (NA) and hemagglutinin (HA) are major membrane glycoproteins found on the surface of influenza virus. Hemagglutinin binds to the sialic acid-containing receptors on the surface of host cells during initial infection and at the end of an infectious cycle. Neuraminidase, on the other hand, cleaves the HA-sialic acid bondage from the newly formed virions and the host cell receptors during budding. Neuraminidase thus is described as a receptor-destroying enzyme which facilitates virus release and efficient spread of the progeny virus from cell to cell.