You searched for: Proteins and Peptides

Supplier: STEMCELL Technologies

FRET-based peptide substrate for detection of protease activity of coronaviruses - 1000 tests.

Supplier: Biorbyt

Human recombinant Epidermal Growth Factor (from E. coli)

Supplier: Biorbyt

Rat VEGF related (from insect cells (Sf9))

Supplier: ACROBIOSYSTEMS

Human recombinant sonic hedgehog (from HEK293)

Supplier: ACROBIOSYSTEMS

Human recombinant CD200 R1 (from HEK293)

Supplier: ACROBIOSYSTEMS

Human recombinant OX40 Ligand (from HEK293)

Supplier: STEMCELL Technologies

Platelet-derived growth factor (PDGF) is a dimeric glycoprotein consisting of two disulfide bridge-stabilized polypeptide chains, A and B, which are assembled as heterodimers (PDGF-AB) or homodimers (PDGF-AA and PDGF-BB) (Fretto et al.; Westermark and Heldin). PDGF signals through the receptor tyrosine kinases PDGFRalpha and PDGFRbeta. It has been shown that PDGF-induced migration involves signaling pathways involving MEK/ERK, EGFR, Src, and PI3K/AKT (Kim et al.). PDGF is a potent mitogen for cells of mesenchymal origin- like fibroblasts, glial cells, and vascular smooth muscle cells. PDGF has been implicated in pathogenesis of atherosclerosis, glomerulonephritis, cancer, and in the contraction of vascular smooth muscle cells of rat aortic tissues (Fretto et al.; Sachinidis et al.). It has been shown that PDGF-AB together with 5-Azacytidine (Catalog #72012), induces the conversion of mature bone and fat cells into tissue-regenerative multipotent stem cells (Chandrakanthan et al.).

Supplier: Biorbyt

Human Recombinant CD14-CHO (from CHO cells)

Supplier: Biorbyt

Recombinant herpes simplex virus-1 (HSV-1) glycoprotein G (from S. cerevisiae)

Supplier: Biorbyt

Human lipoprotein, high density (HDL) 2 subfraction (from plasma)

Supplier: Biorbyt

Recombinant herpes simplex virus-2 (HSV-2) glycoprotein D (from E. coli)

Supplier: STEMCELL Technologies

Human Interleukin 4 (IL-4) is important for immune responses to helminth infection as well as in allergic responses (Olpihant et al.). The IL-4 receptor consists of a heterodimer of IL-4Ra and common gamma chain. IL-4 receptor engagement leads to the activation of JAK1/3 and the recruitment of STAT6 and IRS1/2 (Nelms et al.). IL-4 drives immunoglobulin class switching in B cells (to IgE, IgG4), mast cell hyperplasia, mucus production, and the differentiation of naïve T cells into T helper type 2 (Th2) cells, which produce IL-4, IL-5, IL-10, and IL-13 (Bao et al.; Olpihant et al.; Nelms et al.). In addition to Th2 T cells, IL-4 is produced by CD4+ NK T cells, γ/δ T cells, activated basophils, eosinophils, and mast cells. IL-4 consists of 130 amino acids with a predicted molecular weight of 15.1 kDa. Human IL-4 does not cross-react with mouse cells (Park et al.). This product is animal component-free.

Supplier: ACROBIOSYSTEMS

Human recombinant MUC-17 (from HEK293 cells)

Supplier: ACROBIOSYSTEMS

Human recombinant IgG1 Fc (from HEK293 cells)

Supplier: ACROBIOSYSTEMS

Human recombinant integrin alpha E beta 7 (from HEK293)

Supplier: ACROBIOSYSTEMS

Mouse recombinant serum albumin (from HEK293 cells)

Supplier: ACROBIOSYSTEMS

Human recombinant integrin alpha 8 beta 1 (from HEK293)

Supplier: Roth Carl

Bovine serum albumin (BSA), Fraction V

Supplier: Serva

Bovine serum albumin (BSA), Fraction V

Supplier: Biorbyt

P. falciparum recombinant Plasmodium falciparum (malaria) histidine-rich protein 2 (HRP-2) (from E. coli)

Supplier: ACROBIOSYSTEMS

Human recombinant frizzled-10 (from HEK293 cells)

Supplier: ACROBIOSYSTEMS

Human recombinant IL-1 RAcP (from HEK293 cells)

Supplier: ACROBIOSYSTEMS

Human recombinant transferrin R (from HEK293 cells), Biotin

Supplier: STEMCELL Technologies

Interleukin 10 (IL-10) is the founding member of the IL-10 family of class II cytokines. All of the IL-10 cytokine family members have a four-helix bundle consisting of α-helical folds. Upon binding to its receptor, IL-10 activates signaling through JAK1 and STAT3. It is produced by dendritic cells, macrophages, and CD4+ T regulatory cells, as well as mast cells, NK cells, neutrophils, and regulatory B cells, under specific stimulating conditions (Saraiva and O'Garra). IL-10 can inhibit the activation of certain immune cells while it promotes the function of B cells, and facilitate healing process. Specifically, this cytokine is important for the function of T regulatory cells as it is a potent suppressor of effector T cell proliferation and cytokine production. Also, IL-10 produced by a subset of macrophages inhibits activation and production of pro-inflammatory cytokines by neighboring macrophages, thus allowing a level of self-regulation. IL-10 enhances B cell proliferation, immunoglobulin secretion, and class II MHC expression (Ouyang et al.).

Supplier: STEMCELL Technologies

Tumor necrosis factor-alpha (TNF-α) is a pro-inflammatory cytokine that activates NF-κB, MAPK, and PI3K/AKT pathways. Activated T cells and macrophages are the primary producers of TNF-α in response to inflammation and infectious conditions. Many other cell types have been shown to produce TNF-α, among them B cells, NK cells, mast cells, neutrophils, dendritic cells, microglia, endothelial cells, smooth muscle cells, cardiomyocytes, and fibroblasts. TNF-α has cytotoxic effects on cancerous cells by stimulating anti-tumor immunosuppressive responses. TNF-α stimulates expression of E- and P-selectins, thus facilitating adhesion of neutrophils, monocytes, and memory T cells to activated platelets and endothelial cells (Zelová and Hošek). Other effects of TNF-α include vasodilatation and edema formation. In vitro studies of adult rat neural progenitor cells (NPCs) demonstrate that TNF-α reduces neurogenesis in dentate gyrus-derived NPCs, and promotes astrogliogenesis in subventricular zone-derived NPCs (Borsini et al.).

Supplier: Biorbyt

Human recombinant IFN 1b, INF beta 1b (from E. coli)

Supplier: Biorbyt

Toxoplasma gondii recombinant Toxoplasma gondii p30 (from Escherichia coli)

Supplier: ACROBIOSYSTEMS

Mouse recombinant IL-33 (from HEK293 cells)

Supplier: ACROBIOSYSTEMS

Human recombinant latent TGF-beta 1 (from HEK293)

Supplier: ACROBIOSYSTEMS

Human recombinant IL-12B and IL-12A (from HEK293)