You searched for: Proteins and Peptides

Supplier: ACROBIOSYSTEMS

Mouse recombinant Mesothelin (from HEK293 cells)

Supplier: Biorbyt

Human recombinant Annexin A7 (from E. coli)

Supplier: STEMCELL Technologies

Stimulating T cells with HHV1 (gD) Peptide pool releases downstream cytokines and upregulates activation markers, enabling antigen-specific T cells to be detected or isolated for analysis. HHV1 (gD) Peptide pool is a lyophilised mixture of 96 peptides from envelope glycoprotein D of human herpesvirus 1 (HHV1; strain Patton), and consists of 15-mer peptides with 11-amino-acid overlaps that cover amino acids 1 to 394 on gD. gD is required at the first stage of virus-induced membrane fusion (Subramanian and Geraghty), which likely occurs via binding to receptors such as nectin-1 (Giovine et al.) and HVEM (Connolly et al.) on cell surfaces. Viral peptide pools are useful for a broad range of applications, including vaccine development, immunological research, and diagnostic assay development.

Supplier: ACROBIOSYSTEMS

Human recombinant LILRB4 (from HEK293 cells)

Supplier: ACROBIOSYSTEMS

Human recombinant LILRA2 (from HEK293)

Supplier: Biorbyt

Influenza A, H1N1 New Caledonia 20/99 Hemagglutinin

Supplier: Biorbyt

Human adiponectin glycosilated HEK (from HEK293 cells)

Supplier: Biorbyt

Human recombinant CTLA4 (from Insect cells (Sf9))

Supplier: ACROBIOSYSTEMS

Cynomolgus CD24 Protein, Fc Tag.

Supplier: ACROBIOSYSTEMS

Human recombinant NKG2D (from HEK293 cells)

Supplier: STEMCELL Technologies

Insulin-like growth factor 1 (IGF-I) is a polypeptide that belongs to the family of insulin-like growth factors that are similar in molecular structure to proinsulin. IGF-I binds to the IGF-I receptor and is a potent activator of the PI3K/AKT pathway and also activates ERK1/2 signaling. IGF-I is required for embryonic development, and it is produced mainly in the liver in response to a hepatocyte growth hormone. In the absence of insulin, IGF-I is necessary for the maintenance of human pluripotent stem cells (Wang et al.). Together with IL-3, IGF-I stimulates differentiation and proliferation of myeloid cells and has been shown to regulate lymphopoiesis by stimulating proliferation and differentiation of T and B cells in lymphoid organs (Heemskerk et al.). This product is animal component-free.

Supplier: STEMCELL Technologies

Receptor activator of nuclear factor kappa-B ligand (RANKL) is a member of the tumor necrosis factor (TNF) superfamily (Anderson et al.). Cytokines in the TNF superfamily are involved in a variety of long-term cellular activities such as differentiation, proliferation, and cell death (MacEwan). RANKL is a type II homotrimeric transmembrane protein expressed in both a membrane-bound and secreted form (Ikeda et al.). RANKL binds to the receptor activator of nuclear factor kappa-B (RANK). Upon binding to its receptor, RANKL activates the AKT signaling pathway (Moon et al.). Osteoprotegerin (OPG) may also bind RANKL, and this binding competes with RANKL-RANK binding (Lacey et al.). RANKL is involved in osteoclastogenesis (Lacey et al.; Yasuda et al.) and T cell activation (Wong et al.). This product is animal component-free.

Supplier: Biorbyt

Human recombinant PI3Kb (from insect cells (Sf9))

Supplier: Biorbyt

Human recombinant serpin A6 (from HEK293 cells)

Supplier: Biorbyt

Human recombinant IFN alpha 2B (from Bacteria)

Supplier: Biorbyt

Human recombinant HSAIFN alpha 2b (from Bacteria)

Supplier: Biorbyt

Human recombinant Activin RIIA (from HEK293 cells)

Supplier: Serva

Bestatin ([S-(R*,S*)]-N-(3-amino-2-hydroxy-4-phenylbutyroyl)-L-leucine)

Supplier: STEMCELL Technologies

Monocyte chemotactic protein-1 (MCP-1), also known as CCL2, is a member of the CC family of chemokines. The protein is primarily induced by platelet-derived growth factor (PDGF) gene (Cochran et al.). The biological effects of MCP-1 are mediated via the specific G-protein-coupled receptor CCR2 which in turn activates signal transduction pathways leading to monocyte transmigration (Sozzani et al.). Migration of monocytes from the bloodstream across the vascular endothelium is required for routine immunological surveillance of tissues, as well as other immunomodulatory effects. MCP-1 is produced by a variety of cell types, including fibroblasts and endothelial, epithelial, smooth muscle, mesangial, astrocytic, monocytic, and microglial cells, which are important for antiviral responses in the peripheral circulations and in tissues (Cushing et al.; Deshmane et al.). MCP-1 plays a role in physiological processes such as neurogenesis, neuroprotection, and neurotransmission and has important implications in neurological disorders such as multiple sclerosis and Alzheimer’s disease, in which it is produced during neuroinflammation at the sites of lesions (Conductier et al.).

Supplier: ACROBIOSYSTEMS

Human recombinant IL-29 (from HEK293)

Supplier: STEMCELL Technologies

Granulocyte-macrophage colony-stimulating factor (GM-CSF) promotes the proliferation and differentiation of hematopoietic progenitor cells and the generation of neutrophils, eosinophils, and macrophages. In synergy with other cytokines such as stem cell factor, IL-3, erythropoietin, and thrombopoietin, it also stimulates erythroid and megakaryocyte progenitors (Barreda et al.). GM-CSF is produced by multiple cell types, including stromal cells, Paneth cells, macrophages, dendritic cells (DCs), endothelial cells, smooth muscle cells, fibroblasts, chondrocytes, and Th1 and Th17 T cells (Francisco-Cruz et al.). The receptor for GM-CSF (GM-CSFR) is composed of two subunits: the cytokine-specific α subunit (GMRα; CD116) and the common subunit βc (CD131) shared with IL-3 and IL-5 receptors (Broughton et al.). GM-CSFR is expressed on hematopoietic cells, including progenitor cells and immune cells, as well as non-hematopoietic cells. Recombinant human GM-CSF (rhGM-CSF) promotes the production of myeloid cells of the granulocytic (neutrophils, eosinophils and basophils) and monocytic lineages in vivo. It has been tested for mobilisation of hematopoietic progenitor cells and for treating chemotherapy-induced neutropenia in patients. GM-CSF is able to stimulate the development of DCs that ingest, process, and present antigens to the immune system (Francisco-Cruz et al.). This product is animal component-free.

Supplier: ACROBIOSYSTEMS

Human recombinant NKG2C & CD94 (from HEK293 cells)

Supplier: Biorbyt

Human recombinant serpin G1 (from HEK293 cells)

Supplier: ACROBIOSYSTEMS

Biotinylated Human Nectin-4 Protein, His,Avitag™.

Supplier: ACROBIOSYSTEMS

Rabbit Complement C5 protein, His Tag.

Supplier: ACROBIOSYSTEMS

Human recombinant IgG1 Fc (from HEK293 cells)

Supplier: ACROBIOSYSTEMS

Human recombinant integrin alpha V beta 8 (from HEK293)

Supplier: ACROBIOSYSTEMS

Human recombinant integrin alpha V beta 8 (from HEK293)

Supplier: ACROBIOSYSTEMS

Human recombinant CD30 ligand (from HEK293)

Supplier: ACROBIOSYSTEMS

Human recombinant VEGF R3 (from HEK293)