Rofecoxib is a non-steroidal anti-inflammatory drug that inhibits cyclooxygenase (COX)-2 activity with 1,000-fold selectivity over t hat of COX-1 (IC50s = 26 nM and > 50 µM in human osteosarcoma cells).{12018} In in vivo rodent models, rofecoxib can 1 * 500 mg
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