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Anti-EPCR (CD201) Rat Monoclonal Antibody [clone: RMEPCR1560 (1560)]
  STMC60038
 :  STEMCELL Technologies
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Anti-EPCR (CD201) Rat Monoclonal Antibody [clone: RMEPCR1560 (1560)]
  STMC60038
 :  STEMCELL Technologies

 

  • Antigen name:
    EPCR (CD201)
  • Clonality:
    Monoclonal
  • Clone:
    RMEPCR1560 (1560)
  • Conjugation:
    Unconjugated
  • Host:
    Rat
  • Isotype:
    IgG2b kappa
  • Reactivity:
    Mouse
  • Environmentally Preferable:
  • Gene ID:
    19124
  • Size:
    100 µg
  • Pk:
    0,2 mL

 

 

Rat monoclonal IgG2b antibody against mouse EPCR (CD201), unconjugated.

  • Endothelial cells
  • Hematopoietic Stem
  • Progenitor cells

The RMEPCR1560 (1560) antibody reacts with the endothelial protein C receptor (EPCR or CD201), an ~25 kDa type I transmembrane glycoprotein expressed by endothelial cells, subsets of hematopoietic stem cells (HSCs) and dendritic cells, and several malignant cell lines. It is also found in a soluble form in plasma. EPCR exhibits homology with the MHC class 1/CD1 protein family. EPCR binds protein C and activated protein C, thus augmenting protein C activation by the thrombin-thrombomodulin complex and regulating blood coagulation and inflammation. EPCR protein expression has been detected on ~1.5% of mouse bone marrow cells. Purified EPCR+ cells are highly enriched for HSC activity, as evidenced by high in vivo repopulation activity. Moreover, EPCR expression is associated with the stem cell activity of bone marrow cell populations isolated using conventional markers, indicating the usefulness of EPCR as a single marker for the identification of mouse HSCs.

 : Product restrictions: (i) Customer shall not make products or any portion of them in any way, shape or form, including as a component of another product available for the purpose of further resale or alter or remove the Product label and the Supplier’s mark of origin without express written permission of Supplier and (ii) Customer is familiar with Supplier’s restrictions on the use of the products and shall use the products in compliance with such restrictions and the applicable Supplier Product Information sheet (collectively, the 'Product Restrictions').

Type:
Antigen: EPCR (CD201)
Clonality: Monoclonal
Clone: RMEPCR1560 (1560)
Conjugation: Unconjugated
Epitope:
Host: Rat
Isotype: IgG2b kappa
Reactivity: Mouse