Human Recombinant GDF-5
Catalog # STMC78111.1
Supplier: STEMCELL Technologies
CAS Number:
Specifications
- Pk:100 µG
- Protein/peptide type:Recombinant
- Species:Human
- Seq:1286
- Protein/peptide name:GDF-5
- Purity:≥95%
Specifications
About this item
Growth differentiation factor 5 (GDF-5) is a member of the bone morphogenetic protein (BMP) subclass of the transforming growth factor beta (TGF-β) superfamily. It binds a receptor complex comprising BMPR1B and BMPR2, which then activates the SMAD signaling pathway (Carreira et al.; Nishitoh et al.; Osório et al.). GDF-5 enhances chondrogenic differentiation of mesenchymal stem cells, skeletogenesis, and dendrite growth during development (Coleman et al.; Francis-West et al.). Studies in rat demonstrated that GDF-5 regulates patterning, neurogenesis, astrogliogenesis, and neuronal specification (Gajavelli et al.; Krieglstein et al.; O’Keeffe et al.).
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