- Antibody type:Primary
- Antigen name:HIF2 alpha
- Clonality:Polyclonal
- Conjugation:Alexa Fluor® 750
- Flow cytometry:Yes
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Reactivity:Monkey,Sheep,Human,Rat,Mouse
- Western blot:Yes
- Epitope:1-130/874
- Form:Liquid
- Gene ID:13819
- Antigen synonyms:bHLHe73|HRF|HIF-2alpha|HIF2A|HIF-related factor|EPAS-1|HLF|MOP2|HIF-1-alpha-like factor|HIF2-alpha|Epas1|Endothelial PAS domain-containing protein 1|HIF-2-alpha|mHLF|Hypoxia-inducible factor 2-alpha
- Modification:Unmodified
- Storage buffer:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Molecular weight:96 kDa
- Storage temperature:Store at –20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentration:1 µg/µl
- Shipping temperature:4 °C
- Immunogen:KLH conjugated synthetic peptide derived from mouse HIF2 Alpha
- Tested applications:ICC
- Purification:Purified by Protein A
- Pack type:Vial
- Pk:100 µl
Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBPB and probably EP3. Interaction with redox regulatory protein APEX seems to activate CTAD (By similarity).
Type: Primary
Antigen: HIF2 alpha
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 750
Public Immunogen Range: 1-130/874
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat, Sheep, Monkey