Ac-DEVD-CHO

Caspase-3 inhibitor

Highly specific, potent and reversible inhibitor of caspase-3. Ki<1 nM for purified caspase-3. IC50=0,2 nM for PARP cleavage in cultured human osteosarcoma cell extracts. In contrast, the caspase-1 (ICE) specific inhibitor YVAD-CHO has a Ki=12 µM for caspase-3 and IC50>10 µM for PARP cleavage in osteosarcoma cell extracts. The DEVD sequence is based on PARP cleavage site Asp-216 for caspase-3.

Reconstitution instructions:
Add 0,2 ml DMSO per 1 mg peptide. Shake well until all the contents are dissolved. This furnishes a 10 mM solution of this material.
Protein/peptide name:
Ac-DEVD-CHO
Purity:
>95% (HPLC)
Formulation:
Lyophilized