- Antibody type:Primary
- Antigen name:Integrin Alpha 5
- Antigen symbol:ITGA5
- Clonality:Monoclonal
- ELISA:Yes
- Flow cytometry:Yes
- Host:Mouse
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- ImmunoPrecipitation:Yes
- Isotype:IgG1
- Reactivity:Human
- Seq:02
- Form:Liquid. In PBS containing 1 mg/ml BSA and 0,05% sodium azide.
- Antigen synonyms:MSK8|Vitronectin Receptor Subunit Alpha|CD51|ITGAV|Vitronectin Receptor|VNRA|VTNR
- Concentration:0,2 mg/ml
- Purification:Protein A-affinity purified
- Pk:100 µG
CD51 (integrin αV subunit) associates with CD61 (integrin β3 subunit) binding to the RGD sequence in extracellular matrix proteins like vitronectin, fibrinogen, thrombospondin, von Willebrand factor and osteopontin. The αV/β3 heterodimer is expressed in endothelial cells, leukocytes, NK cells, macrophages, neutrophils, platelets and several malignant tumor cells and seems to play a role in embryo implantation, angiogenesis, wound healing and cancer. αV/β3 is also highly expressed in osteoclasts being important for bone resorption.
- For ELISA, Flow Cytometry, Immunoprecipitation
Recognizes human CD51 (alphaV integrin). Recognizes heterodimers alphaVbeta3, alphaVbeta1, alphaVbeta5 and alphaVbeta6. Does not cross-react with other species.
Type: Primary
Antigen: ITGAV
Clonality: Monoclonal
Clone:
Conjugation:
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human