Specifications
- Pk:100 µG
- Protein/peptide type:Recombinant
- Source:CHO cells
- Species:Human
- Tag sequence:Fc Tag
- Storage conditions:Stable for at least 1 year after receipt when stored at −20 °C. Working aliquots are stable for up to 3 months when stored at −20 °C.
- Biological activity:Measured by its ability to inhibit the proliferation of mouse T cells induced by CD27 ligand and anti-CD3.
- Protein synonyms:S152|T14|Tumor Necrosis Factor Receptor Superfamily Member 7|TNFRSF7|T Cell Activation Antigen CD27
- Protein/peptide name:CD27
- Purity:>98% (SDS-PAGE)
- Sequence:21-192
- Formulation:Lyophilized from 0.2um-filtered solution in PBS.
Specifications
About this item
CD27 (TNFRSF7) is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage and exists as both a dimeric glycoprotein on the cell surface and as a soluble protein in serum. As a T and B cell co-stimulatory molecule, the activity of CD27 is governed by its TNF-like ligand CD70 on lymphocytes and dendritic cells. The CD27-CD70 interaction is required for Th1 generation responses to differentiation signals and long-term maintenance of T cell immunity, and meanwhile, plays a key role in regulating B cell differentiation, activation and immunoglobulin synthesis. The CD27 receptor transduces signals and subsequently leads to the activation of NF-kappaB and MAPK8/JNK, mediated by the adaptor proteins TRAF2 and TRAF5. In addition, the proapoptotic protein SIVA is capable of binding the cytoplasmic tail of CD27 and exerts action in the process of apoptosis.
Fusion-Tag: Fc Tag
This recombinant proteins is for research use only.