Specifications
- Pk:50 µG
- Protein/peptide type:Recombinant
- Source:E. coli
- Species:Human
- Tag sequence:N, C-6 His tag
- Storage conditions:Store at −20 °C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.
- Protein synonyms:PAGA|Peroxiredoxin-1|PAG|Proliferation-associated gene protein|PRDX1|Thioredoxin-dependent peroxide reductase 2|Natural killer cell-enhancing factor A|NKEF-A|TDPX2|PAGB|Thioredoxin peroxidase 2
- Protein/peptide name:Peroxiredoxin 1
- Purity:> 95% as determined by reducing SDS-PAGE
- Molecular weight:25.3 kD
- Sequence:Met1-Lys199
- Formulation:Supplied as a 0.2 um filtered solution of PBS, 10% glycerol, 0.1mM DTT,pH 6.0. Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
- Tested applications:Bioassay
Specifications
About this item
Peroxiredoxin-1(PRDX1) contains 1 thioredoxin domain and belongs to the AhpC/TSA family. PRDX1 constitutively expressed in most human cells and it is induced to higher levels upon serum stimulation in untransformed and transformed cells. PRDX1 is involved in redox regulation of the cell. It reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin and play an important role in eliminating peroxides generated during metabolism. PRDX1 might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H2O2. It reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation. It may contribute to the antiviral activity of CD8(+) T-cells and have a proliferative effect in cancer development or progression.
Fusion-Tag: N, C-6 His tag
This recombinant protein can be used for biological assays. For research use only.