Specifications
- Antibody type:Primary
- Antigen name:Macrophage Stimulating 1 Receptor
- Antigen symbol:MST1R
- Clonality:Polyclonal
- Conjugation:Alexa Fluor® 488
- Host:Rabbit
- ImmunoChemistry:Yes
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Cross adsorption:No
- Form:liquid
- Gene ID:4486
- Antigen synonyms:soluble R|RON variant E2E3|MST1R variant RON30|PTK8|macrophage-stimulating protein receptor|MST1R variant RON62|soluble RON variant 1|c-met-related tyrosine kinase|CDw136|PTK8 protein tyrosine kinase 8|MSP receptor|p185-Ron|soluble RON variant 3|RON|soluble RON variant 2|CD136
- Modification:phospho-Tyr1238/Tyr1239
- Storage buffer:Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
- Storage temperature:Store at 4°C for 12 months
- Concentration:1 μg/μl
- Shipping temperature:4°C
- Immunogen:1235-1245/1400
- Purification:Purified by Protein A
- Pk:100 µl
Specifications
About this item
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.
Recommended Dilutions: IF(IHC-P): 1:50-200
Type: Primary
Antigen: MST1R
Clonality: Polyclonal
Clone:
Conjugation: Alexa Fluor® 488
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat