Poroshell 300 columns are ideal for fast separations of proteins and peptides because the superficially porous particle allows for fast flow rates to be used while maintaining sharp, efficient peaks. Peptides and proteins are typically separated slowly to reduce the potential peak broadening of these slow diffusing analytes. However, Poroshell columns use a superficially porous particle made with a thin layer of porous silica on a solid core of silica, reducing the diffusion distance for proteins making practical rapid HPLC separations of peptides and proteins up to 500 to 1000 kDa.

• They bonded with StableBond bonded phases provide excellent stability and selectivity choices with TFA and formic acid mobile phases
• High-resolution separations of biomolecules with superficially porous particles
• High efficiency and recovery with proteins (up to 1000 kDa) and monoclonal antibodies