"Other Essentials"

Supplier: Bioss

ADCK2 (aarF domain containing kinase 2), also known as AARF, is a 626 amino acid single-pass membrane protein belonging to the protein kinase superfamily and the ADCK protein kinase family. The ADCK family consists of five paralogs in human (ADCK1-5). Encoded by a gene that maps to human chromosome 7q34, ADCK2 contains one protein kinase domain. ADCK2 participates in ATP and nucleotide binding, transferase functions and protein serine/threonine kinase activities. Expression of ADCK2 inversely correlates with cellular viability, suggesting elevated expression of ADCK2 may be essential for tumour survival. ADCK2 is necessary for cell proliferation of glioblastoma multiforme (GBM), a fatal primary brain tumor containing countless genetic and epigenetic alterations.

Supplier: Cayman Chemical

TAK-242 ≥98%

Supplier: Cytiva

Capto™ HiRes Q and Capto™ HiRes S are prepacked columns for high-resolution purification of proteins and other biomolecules by ion exchange chromatography. They are well-suited for the preparation of highly pure proteins for structural studies and for protein analysis.

Supplier: Abcam

Anti-FAK (phospho Y397 + Y576 + Y925) antibody [RM1141] is a Rabbit Recombinant Multiclonal antibody that is used in FAK (phospho Y397 + Y576 + Y925) Dot Blot, Western Blot. Suitable for Human, Mouse, Rat samples. FAK (PTK2) is a non-receptor protein-tyrosine kinase which is involved in regulation of a number of essential cellular processes, including cell cycle progression, cell migration, actic cytoskeleton organisation and formation of focal adhesions. FAK is activated by phosphorylation and recruited to focal adhesions in response to integrin signalling. Aberrant expression of FAK may play a role in tumor formation, including ovarian, breast and non-small cell lung cancers.

Supplier: Biosensis

FUNCTION: Required for autophagy. Conjugates to ATG12 and associates with isolation membrane to form cup-shaped isolation membrane and autophagosome. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed. FUNCTION: May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. SUBCELLULAR LOCATION: Cytoplasm. Colocalizes with nonmuscle actin. ALTERNATIVE PRODUCTS: 2 named isoforms produced by alternative splicing. TISSUE SPECIFICITY: Ubiquitous. The mRNA is present at similar levels in viable and apoptotic cells, whereas the protein is dramatically highly expressed in apoptotic cells. INDUCTION: By apoptotic stimuli. PTM: Conjugated to ATG12; which is essential for autophagy, but is not required for association with isolation membrane. SIMILARITY: Belongs to the ATG5 family.

Supplier: HIMEDIA

Sterility test medium also used for cultivation of soyabean casein digest medium.

Supplier: Thermo Fisher Scientific

Pierce™ Recombinant Peroxidase Conjugated Protein A can be used to probe and detect rabbit and human antibodies, especially IgG isotypes, in Western blotting, ELISA, IHC and other immunoassay protocols.

Supplier: Abcam

Anti-CRBN antibody [EPR28739-64] is a Rabbit Monoclonal antibody that is used in CRBN Flow Cytometry (Intra), IP, Western Blot. Suitable for Human, Mouse samples. Cereblon (CRBN) is a multifunctional protein located in the cytoplasm, nucleus, and peripheral membranes of the human tissues. CRBN is closely related to the proliferation and metabolism of normal cells as well as tumor cells.It is part of the CRL4 CRBN ubiquitin E3 ligase complex, which is crucial for the action of immunomodulatory drugs (IMiDs) like lenalidomide and pomalidomide. These drugs bind to CRBN, leading to the degradation of transcription factors Ikaros and Aiolos, which are essential for myeloma cell survival. Additionally, novel cereblon E3 ligase modulators (CELMoDs) are being developed to overcome resistance to IMiDs, offering new therapeutic options for patients with CRBN mutation.

Supplier: MP Biomedicals

An essential fatty acid, and a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes. Occurs in liver, brain, glandular organs, and depot fats of animals, in small amounts in human depot fats, and is a constituent of animal phosphatides.

Supplier: Biosensis

CNTF is a survival promoting factor for different types of neurons in vitro and in vivo. The essential structural features for the biological function of human CNTF were investigated by Thier, M. et al. They showed that deletion of 14 N-terminal and 18 C-terminal amino acids significantly increased bioactivity compared to wild-type CNTF. FUNCTION: CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy. SUBUNIT: Homodimer. SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Nervous system. PHARMACEUTICAL: CNTF is being tested under the name Axokine by Regeneron Pharmaceuticals for treatment of human motor neuron diseases, such as amyotrophic lateral sclerosis (ALS). As it induces substantial weight loss, preferentially of fat as opposed to lean body mass, it is being used for obesity treatment. SIMILARITY: Belongs to the CNTF family.

Supplier: MP Biomedicals

Tryptone is a pancreatic digest of casein, utillised as a source of nitrogen in many culture media for growing bacteria as well as fungi.

Supplier: Cayman Chemical

S396A mutant (from E. coli)

Supplier: BOEKEL SCIENTIFIC

RapidFISH slide hybridisation oven was designed to simplify fluorescent in-situ hybridisations procedures for FFP samples, cell suspensions, and other tissue preparation procedures.

Supplier: AAT Bioquest

Optimised for CytoCite™ and Qubit™ fluorometers. The Portelite™ fluorimetric protein quantitation kit is significantly more sensitive than existing colorimetric protein measurements, e.g., Bradford and Bicinchoninic acid (BCA) assays.

Supplier: Boster Bio

Rabbit IgG polyclonal antibody for NLR family CARD domain-containing protein 4(NLRC4) detection. Tested with WB in Human;Mouse;Rat.

Supplier: Merck

MVP ICON® portable hygiene monitoring system – setting a new standard.