1062 Ergebnisse für: "Other Essentials"

Supplier: Bioss

NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalisation as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators. The NF-kappa-B p65-p65 complex appears to be involved in invasin-mediated activation of IL-8 expression. The inhibitory effect of I-kappa-B upon NF-kappa-B the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells (PubMed:15790681).

Supplier: STEMCELL Technologies

Stem cell factor (SCF) is an early-acting cytokine that plays a pivotal role in the regulation of embryonic and adult hematopoiesis. SCF promotes cell survival, proliferation, differentiation, adhesion, and functional activation of cells at multiple levels of the hematopoietic hierarchy. Together with other cytokines such as thrombopoietin and Flt3/Flk-2 Ligand, SCF is commonly used to promote expansion of primitive hematopoietic stem cells and multi-potent progenitor cells in culture (Huang et al.; Kent et al.). In synergy with various growth factors, including IL-2, IL-3, IL-6, IL-7, G-CSF, and erythropoietin, SCF increases proliferation and differentiation of myeloid and erythroid progenitor cells and a subset of lymphoid progenitor cells (Broudy). In the mouse, SCF is essential during fetal gonadal development (Mauduit). It is produced by stromal cells in the fetal liver, bone marrow, and thymus, in the central nervous system, in keratinocytes, and in the gut mucosa, and can function as a chemotactic and chemokinetic factor. SCF exists in two biologically active splice forms: a soluble and a transmembrane isoform. Upon binding to its receptor (c-kit tyrosine kinase receptor; CD117), it activates PI3K, JAK/STAT, and MAPK pathways. SCF and signaling from c-kit has also been reported to play an important role in pigmentation, fertility, vasculogenesis, motility of the gut via c-kit-positive interstitial cells of Cajal, and in the migration of neuronal stem and progenitor cells to sites of injury in the brain (Lennartsson and Ronnstrand).

Supplier: ProSci Inc.

MBD1 belongs to a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MBD1 can also repress transcription from methylated gene promoters. Five transcript variants of the MBD1 are generated by alternative splicing resulting in protein isoforms that contain one MBD domain, two to three cysteine-rich (CXXC) domains, and some differences in the COOH terminus. All five transcript variants repress transcription from methylated promoters; in addition, variants with three CXXC domains also repress unmethylated promoter activity. DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. Five transcript variants of the MBD1 are generated by alternative splicing resulting in protein isoforms that contain one MBD domain, two to three cysteine-rich (CXXC) domains, and some differences in the COOH terminus. All five transcript variants repress transcription from methylated promoters; in addition, variants with three CXXC domains also repress unmethylated promoter activity. MBD1 and MBD2 map very close to each other on chromosome 18q21.

Supplier: Merck

Chlorimuronethyl ist ein Sulfonylharnstoff-Herbizide, die häufig zur Bekämpfung breitblättriger Unkräuter in Sojabohnen, Mais, Erdnüssen, Bohnen und anderen Nutzpflanzen vor und nach dem Auflaufen eingesetzt werden. Es zeichnet sich durch sehr niedrige Anwendungsmengen, hohe herbizide Aktivität, gute Nutzpflanzenselektivität und geringe Toxizität aus. Chlorimuronethyl ist ein Acetolactatsynthase (ALS)-Hemmer, der durch Hemmung der Biosynthese der essentiellen Aminosäuren wie Valin, Leucin und Isoleucin wirkt. Dies stoppt das Pflanzenwachstum, da die Zellteilung wachsender Wurzeln und Sprossspitzen gehemmt wird.

Supplier: VWR Collection

Die Wandhalterung mit variablen Haltepunkten bietet Platz für bis zu vier verschiedene Spenderboxen für Persönliche Schutzausrüstung oder andere Laborartikel. Sie eignet sich für verschieden große Boxen von Handschuhen, Gesichtsschutzmasken, Ohrstöpseln oder Überschuhen.

Supplier: MERCK PRODUCTION CHEMICALS

Other residual solvents acc. to ICH-guideline are excluded by the manufacturing process.
Residues of metal catalysts or metal reagents acc. to EMEA/CHMP/SWP/4446/2000 are not likely to be present.
Corresponds to Ph Eur, JP

Supplier: Biowest

L-Glutamin ist eine essentielle Aminosäure, die von praktisch allen in Kultur gezüchteten Säugetier- und Insektenzellen benötigt wird. Es ist ein entscheidender Bestandteil vieler Zellkulturmedien und dient als wichtige Energiequelle für Zellen in Kultur. L-Glutamin ist als Trockenpulver und als gefrorene Lösung sehr stabil. In flüssigen Medien oder Stammlösungen kann L-Glutamin jedoch relativ schnell abgebaut werden. L-Glutamin ist labiler in Zellkulturlösungen als andere Aminosäuren.

Supplier: Sartorius

Die Eliminierung von Partikeln aus Proben vor der HPLC oder einer anderen chromatographischen Analyse ist wesentlich, um die Integrität der Chromatographiesäule zu erhalten und ihre Betriebslebensdauer zu maximieren. Für die Probenvorbereitung optimierte Minisart® Spritzenfilter bestehen aus einem Polypropylen (PP)-Gehäuse und Membrankomponenten mit maximaler chemischer Kompatibilität und minimal extrahierbaren Stoffen, um hervorragende Ergebnisse zu gewährleisten. Aufgrund des typischen Volumenbereichs von weniger als 1 ml bis 100 ml sind diese Filter in drei verschiedenen Durchmessern mit einer effektiven Filterfläche von 0,12, 1,7 und 4,8 cm² erhältlich.

Supplier: MERCK PRODUCTION CHEMICALS

Corresponds to Ph. Eur., BP, USP, E 307
Conforms to the purity criteria on food additives according to the current European Commission Regulation.
# specified acc. to EMEA/CHMP/SWP/4446/2000 (Specification limits for residues of metal catalysts or metal reagents).
Other residues of metal catalysts or metal reagents acc. to this guideline are not likely to be present.

Supplier: JUSTRITE MANUFACTURING

Diese Sicherheitskanister für ölige Abfälle mit Gehäuse aus verzinktem Stahl und langlebiger Pulverbeschichtung sind unverzichtbar bei der Verwendung von mit Lösungsmitteln getränkten Tüchern und Wischlappen. Mit Verdünner, Leinöl, brennbaren Klebstoffen und anderen brennbaren Flüssigkeiten getränkte Lappen und Tücher stellen bei unsachgemäßer Entsorgung eine ernsthafte Brandgefahr dar.

Supplier: Bioworld Technology

NLRC4 POLYCLONAL ANTIBODY 1 * 100 µG

Supplier: MP Biomedicals

LB Medium is a nutritionally rich medium originally developed for growth and maintenance of E. coli strains. It supports a luxurious growth of E. coli cells as tryptone and yeast extract supply essential growth factors that E. coli cells would otherwise have to synthesise. The medium also contains essential electrolytes for transport and osmotic balance, due to the NaCl component.

Supplier: STEMCELL Technologies

MEM non-essential amino acid solution (100X).

Supplier: HyClone products (Cytiva)

Minimum Essential Medium (MEM) is one of the earliest modifications of Basal Medium Eagle (BME) containing amino acid concentrations that more closely mimic those found in mammalian cells. MEM has been used with serum supplementation on a broad range of cell types including suspension and adherent mammalian cells, HeLa, BHK-21, HEK-293, HEp-2, HT-1080, MCF-7,fibroblasts and primary rat astrocytes.

Supplier: MP Biomedicals

Minimum Essential Medium Eagle With Earle's Salts and 2,0 g/L sodium bicarbonate Without L-glutamine, L-cysteine, L-cystine, and L-methionine is generally used to grow attached cell lines, such as fibroblasts, in the presence of FBS, calf or horse sera.

Supplier: MP Biomedicals

Rich medium for the growth of E. coli and certified for plasmid and other bacterial cultures in liquid medium.

Supplier: Bioss

May contribute to neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.

Supplier: Bioss

May contribute to neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.

Supplier: MP Biomedicals

Rich medium for the growth of E. coli and certified for plasmid and other bacterial cultures in liquid medium.

Supplier: Bioss

In eukaryotes, it is essential to have the ability to detect and degrade transcripts that lack full coding potential. Nonsense-mediated RNA decay (NMD) protects the organism by avoiding the translation of truncated peptides with dominant negative or deleterious gain-of-function potential. Rent1, a mammalian ortholog of Upflp, is essential for embryonic viability (13). Rent1 (also designated regulator of nonsense transcripts and HUpf1) contains an N-terminal zinc finger-like domain, NTPase domains and a region comprised of domains that define Rent1 as a superfamily group I helicase.

Supplier: Bioss

In eukaryotes, it is essential to have the ability to detect and degrade transcripts that lack full coding potential. Nonsense-mediated RNA decay (NMD) protects the organism by avoiding the translation of truncated peptides with dominant negative or deleterious gain-of-function potential. Rent1, a mammalian ortholog of Upflp, is essential for embryonic viability (13). Rent1 (also designated regulator of nonsense transcripts and HUpf1) contains an N-terminal zinc finger-like domain, NTPase domains and a region comprised of domains that define Rent1 as a superfamily group I helicase.

Supplier: MP Biomedicals

Rich medium for the growth of E. coli and certified for plasmid and other bacterial cultures in liquid medium.

Supplier: MP Biomedicals

Rich medium for the growth of E. coli and certified for plasmid and other bacterial cultures in liquid medium.

Supplier: Bioss

Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Essential for cartilage morphogenesis and joint formation. Inhibits chondrocyte differentiation through its interaction with GDF5 (PubMed:21976273).

Supplier: Bioss

Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Essential for cartilage morphogenesis and joint formation. Inhibits chondrocyte differentiation through its interaction with GDF5 (PubMed:21976273).

Supplier: Bioss

Flagellin is the subunit protein which polymerises to form the filaments of bacterial flagella. FlaB/D is not essential for polar flagellar synthesis and swimming motility. Homopolymer of FlaB/D is not able to form a functional filament.

Supplier: Bioss

Flagellin is the subunit protein which polymerises to form the filaments of bacterial flagella. FlaB/D is not essential for polar flagellar synthesis and swimming motility. Homopolymer of FlaB/D is not able to form a functional filament.

Supplier: Merck

This medium is recommended for total heterotrophic microorganism detection in water and other liquid samples.

Supplier: Biotium

The amine reactive succinimidyl ester of TO (thiazole orange) can be conjugated to peptides, proteins, drugs, polymeric materials and biomolecules with primary amine groups. The conjugates are expected to be essentially nonfluorescent until they are able to complex with nucleic acids, resulting in green fluorescence.

Supplier: Biotium

The amine reactive succinimidyl ester of EB (ethidium bromide) can be conjugated to peptides, proteins, drugs, polymeric materials and biomolecules with primary amine groups. The conjugates are expected to be essentially nonfluorescent until they are able to complex with nucleic acids, resulting in red fluorescence.