Anti-HOOK3 Rabbit Polyclonal Antibody

Supplier: Abcam

Rabbit polyclonal to HOOK3.

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Anti-HOXD1 Rabbit Polyclonal Antibody

Supplier: Aviva Systems Biology

Anti-HOXD1 Rabbit Polyclonal Antibody

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Anti-HOOK1 Rabbit Polyclonal Antibody

Supplier: Aviva Systems Biology

Anti-HOOK1 Rabbit Polyclonal Antibody

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Anti-HOXD1 Rabbit Polyclonal Antibody

Supplier: US Biological

Anti-HOXD1 Rabbit Polyclonal Antibody

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Anti-HOXD9 Rabbit Polyclonal Antibody

Supplier: US Biological

Anti-HOXD9 Rabbit Polyclonal Antibody

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Anti-HOXD3 Rabbit Polyclonal Antibody

Supplier: Aviva Systems Biology

Anti-HOXD3 Rabbit Polyclonal Antibody

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Anti-HOXD8 Rabbit Polyclonal Antibody

Supplier: Abgent

Anti-HOXD8 Rabbit Polyclonal Antibody

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Anti-HOXD1 Rabbit Polyclonal Antibody

Supplier: Aviva Systems Biology

Anti-HOXD1 Rabbit Polyclonal Antibody

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Anti-HOXD1 Rabbit Polyclonal Antibody

Supplier: Aviva Systems Biology

Anti-HOXD1 Rabbit Polyclonal Antibody

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Anti-HOXD3 Rabbit Polyclonal Antibody

Supplier: Abcam

Rabbit polyclonal to HOXD3.

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Anti-HOXD1 Rabbit Polyclonal Antibody

Supplier: US Biological

Anti-HOXD1 Rabbit Polyclonal Antibody

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Anti-HOXD8 Rabbit Polyclonal Antibody

Supplier: US Biological

Anti-HOXD8 Rabbit Polyclonal Antibody

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Anti-HOXD9 Rabbit Polyclonal Antibody

Supplier: Bioss

The Hox proteins play a role in patterns of embryonic development and cellular differentiation by regulating downstream target genes. In vivo, the HoxD9 protein interacts with the autoregulatory and cross-regulatory enhancers of the murine HoxB1 and human HoxD9 genes. Specifically, the HoxD9 protein interacts with the human control region (HCR) of the HoxD9 gene, thus inducing transcription of the HoxD9 promoter. HoxD9 may be a multifunctional transcriptional regulator, as it contains different activation domains. Activation of HoxD9 depends on the structure of the target regulatory element, and results in differential cofactor interaction. The HoxD9 protein is expressed in the early stages of mouse joint development, primarily in the articular cartilage. HoxD9 transcripts are also detected in the synovial tissue of arthritic mice, but not in that of normal mice, suggesting that HoxD9 may have a role in the pathology of arthritis. Furthermore, the HoxD9 protein is highly expressed in the synoviocytes of patients with rheumatoid arthritis (RA), but not in osteoarthritis patients. The human HoxD9 protein is also differentially expressed in the human cervical cancer cell line HeLa, but is not expressed in the normal cervix and may thus play a role in tumorigenesis.