12525 Ergebnisse für: "Enzo Life Sciences"

Supplier: Enzo Life Sciences

Isolated from stimulated human neutrophil granulocytes (buffy coat). Requires activation.

Supplier: Enzo Life Sciences

Produced in E. coli. Mature human MMP-14 (aa 89-265).

Supplier: Enzo Life Sciences

Kills Fas-sensitive cells at concentrations of >1 ng/ml in the presence of cross-linking enhancer.

Supplier: Enzo Life Sciences

Isolated from human rheumatoid synovial fibroblasts. Requires activation.

Supplier: Enzo Life Sciences

Peptide fragment from phospholipase A2 (PLA2) activating protein (PLAP) that activates phospholipase A2 in a dose-dependent manner (10-fold at 1 µg/ml).

Supplier: Enzo Life Sciences

For increased cell permeability the peptide was covalently linked to the 10 aa recognized by the TAT transporter.

Supplier: Enzo Life Sciences

Potent, cell permeable, irreversible, and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC50=700pM). Antitumor agent in vivo.

Supplier: Enzo Life Sciences

Potent inhibitor of histone deacetylases (HDACs) (IC50≤1µM).

Supplier: Enzo Life Sciences

Pseudosubstrate prototope of the PKC regulatory domain. Inhibitor of protein kinase C (PKC).

Supplier: Enzo Life Sciences

IL-4 activator

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PPARα activator.

Supplier: Enzo Life Sciences

Potent, water soluble poly(ADP-ribose) polymerase (PARP) inhibitor (EC50=20nM compared to EC50=200µM of the prototypical PARP inhibitor 3-aminobenzamide). Inhibits peroxynitrite-induced cell necrosis (EC50=20nM). Has significant, dose-dependent, anti-inflammatory effects in a variety of local inflammation models and provides cardioprotection by decreasing myocardial infarct size.

Supplier: Enzo Life Sciences

CB1 receptor ligand.

Supplier: Enzo Life Sciences

nNOS inhibitor

Supplier: Enzo Life Sciences

Host: Mouse, Isotype: IgG1

Supplier: Enzo Life Sciences

Host: Mouse, Isotype: IgG1

Supplier: Enzo Life Sciences

The three dimensional structure of many extracellular proteins is stabilized by the formation of disulphide bonds. Studies suggest that a microsomal enzyme known as Protein Disulphide-Isomerase (PDI) is involved in disulphide-bond formation and isomerization, as well as the reduction of disulphide bonds in proteins. PDI, which catalyses disulphide interchange between thiols and protein dilsulphides, has also been referred to as thiol:protein-disulphide oxidoreductase and as glutathione:insulin transhydrogenase because of its role in reduction of disulphide bonds. The highly conserved sequence Lys-Asp-Glu-Leu (KDEL) is present at the carboxy-terminus of PDI and other soluble endoplasmic reticulum (ER) resident proteins including the 78 and 94 kDa glucose regulated proteins (GRP78 and GRP94 respectively). The presence of carboxy-terminal KDEL appears to be necessary for ER retention and appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor.

Supplier: Enzo Life Sciences

Host: Mouse, Isotype: IgG1

Supplier: Enzo Life Sciences

Host: Mouse, Isotype: IgG1

Supplier: Enzo Life Sciences

VASP (vasodilator stimulated phosphoprotein) is a proline-rich protein substrate of cAMP- and cGMP-dependent protein kinases. Phosphorylation of VASP at Ser-157 causes a mobility shift in SDS gel electrophoresis from 46 to 50 kDa, which has been used as a convenient marker to monitor cyclic nucleotide-dependent protein kinase activity. VASP is the founding member of the Ena-VASP protein family, comprising the Drosophila protein Enabled (Ena), its mouse homologue Mena (mammalian Enabled), and mouse EVL (Ena-VASP-like protein). With these proteins VASP shares a conserved overall domain organization:
a) the conserved N-terminal Ena-VASP homology domain 1 (EVH1), which mediates binding to a proline-rich motif,
b) a more divergent proline-rich central domain (which is responsible for profilin binding), and
c) a conserved C-terminal EVH2 domain.

Particularly high VASP levels are present in platelets, although VASP is expressed in a wide variety of cell types and tissues. In cultured cells, VASP is associated with focal adhesions, cell-cell contacts, microfilaments, and highly dynamic membrane regions. From in vitro binding data VASP has been suggested to link profilin to zyxin, vinculin, and the Listeria spp. surface protein ActA, respectively. Functional evidence indicates that VASP is a crucial factor involved in the enhancement of actin filament formation and the actin-dependent motility of intracellular bacterial pathogens.

Supplier: Enzo Life Sciences

The STAT proteins serve as both cytoplasmic signal transducers and nuclear activators of transcription. STAT3 is activated by tyrosine phosphorylation at residue Y705 in cells treated with interleukin-6 or EGF. Activated STAT3 can bind to DNA either as homodimer or as heterodimer with STAT1.

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Glutamate inhibitor

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Mycotoxin. Nephrotoxic.

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Naturally occurring mycotoxin produced by many species of Aspergillus. It is metabolised by the liver to the reactive intermediate aflatoxin M1. Exposure may produce acute necrosis, cirrhosis and carcinoma of the liver. Induces DNA damage.

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Hepatotoxic and hepatocarcinogenic mycotoxin.

Supplier: Enzo Life Sciences

Isolated from Griffonia (Bandeiraea) simplicifolia seeds.

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Host: Mouse, Isotype: IgG1

Supplier: Enzo Life Sciences

Highly specific, potent, irreversible, and cell-permeable competitive inhibitor of proprotein convertases: furin/SPC1 (Ki~1 nM), SPC2/PC2 (Ki=0.36nM), SPC3/PC1/PC3(Ki= 2,0nM), SPC4/PACE4 (Ki=3,6 nM), SPC6/PC5/PC6, and SPC7/LPC/PC7/PC8 (Ki=0,12 nM). Because furin activates viral glycoproteins, this inhibitor is a useful antiviral agent. In addition, it inhibits furin-dependent pro-MMP-2 activation in various cell lines, including U87 and HT1080 cells. Typical concentration range used in tissue culture is 25 to100 µm.

Supplier: Enzo Life Sciences

Host: Rabbit

Supplier: Enzo Life Sciences

Chymostatin