Supplier: Enzo Life Sciences

This peptide, PKTPKKAKKL, is derived from histone H1 and is a substrate for CDK5.

Supplier: Enzo Life Sciences

Ceramide-1-phosphate is mitogenic for fibroblasts.

Supplier: Enzo Life Sciences

CD51 (integrin αV subunit) associates with CD61 (integrin β3 subunit) binding to the RGD sequence in extracellular matrix proteins like vitronectin, fibrinogen, thrombospondin, von Willebrand factor and osteopontin. The αV/β3 heterodimer is expressed in endothelial cells, leukocytes, NK cells, macrophages, neutrophils, platelets and several malignant tumor cells and seems to play a role in embryo implantation, angiogenesis, wound healing and cancer. αV/β3  is also highly expressed in osteoclasts being important for bone resorption.

Supplier: Enzo Life Sciences

Host: Goat

Supplier: Enzo Life Sciences

Inhibitor of non-muscle myosin II

Supplier: Enzo Life Sciences

ADP-ribosylation factor inhibitor

Supplier: Enzo Life Sciences

Immunosuppressant

Supplier: Enzo Life Sciences

Lincosamide antibiotic. 23S Inhibits bacterial protein synthesis. Active against Gram-positive bacteria. Lincomycin binds to the 50S subunit of bacterial ribosomes and suppresses protein synthesis.

Supplier: Enzo Life Sciences

Cyclic hydroxylamine spin probe for in vivo, intraperitoneal and intravenous injections.

Supplier: Enzo Life Sciences

Produced in Sf9 cells. Active, full length protein kinase C mu (PKCµ, protein kinase D, PKD) is fused at the N-terminus to a GST-tag.

Supplier: Enzo Life Sciences

The Screen-Well™ Phosphatase Inhibitor Library contains 33 known phosphatase inhibitors of well-defined activity. Inhibitors are supplied dissolved in DMSO at 10 mM and aliquoted into deep-well plates at either 100 µl or 500 µl per well. The library is ideal for chemical genomics, assay development, and as a reference set for secondary screening. Includes inhibitors of these important phosphatases: Calcineurin(PP2B), JSP-1, PRL-1, CD45, PP1, PRL-3, CDC25, PP2A, PTEN, and many more.

Supplier: Enzo Life Sciences

The Screen-Well® neurotransmitter library contains 681 CNS receptor ligands in a 96-well format. Ideal for screening or identifying recombinant orphan G protein-coupled receptors, target validation, secondary screening, validating new assays, and for routine pharmacological applications.

Supplier: Enzo Life Sciences

The adrenergic ligand library contains 84 ligands including endogenous neurotransmitters, agonists, antagonists, and marketed drugs. The library is ideal for screening or identifying recombinant orphan G protein-coupled receptors, target validation, secondary screening, assay development, and other pharmacological applications. The adrenergic ligand library is 1 plate of the larger neurotransmitter library which contains over 650 CNS receptor ligands.

Supplier: Enzo Life Sciences

Isolated from giant keyhole limpet (Megathura crenulata).

Supplier: Enzo Life Sciences

Inhibits cytochrome P-450-mediated prostaglandin ω/ω-1 hydroxylase activity.

Supplier: Enzo Life Sciences

Host: Rabbit

Supplier: Enzo Life Sciences

Host: Rabbit

Supplier: Enzo Life Sciences

Tripeptidyl peptidase inhibitor

Supplier: Enzo Life Sciences

Na+ channel blocker, K+ channel activator

Supplier: Enzo Life Sciences

Proteasome inhibitor

Supplier: Enzo Life Sciences

Cathepsin inhibitor

Supplier: Enzo Life Sciences

Produced in E. coli.

Supplier: Enzo Life Sciences

This peptide, EFGTYGTLSKKK, is derived from a peptide (pF4) discovered, through phage display, to be a very good substrate for Fyn kinase.

Supplier: Enzo Life Sciences

Produced in E. coli. Active soluble BACE1.

Supplier: Enzo Life Sciences

Produced in insect cells. Active soluble (truncated at aa 595) furin.

Supplier: Enzo Life Sciences

14-3-3 inhibitor

Supplier: Enzo Life Sciences

Marine sesterterpenoid. Structurally related to manoalide. Anti-inflammatory phospholipase A2 (PLA2) inhibitor (IC50=0.23µM). Less potent than manoalide, but partially reversible (IC50=0.23µM, bee venom PLA2). Inhibits human recombinant sPLA2 (IC50=9.3µM) selectively over cPLA2.

Supplier: Enzo Life Sciences

PKC activator.

Supplier: Enzo Life Sciences

DNA-topoisomerase II, also known as Topo II or Top 2, is a multifunctional nuclear enzyme required during DNA replication, chromosome disjunction at mitosis, and other DNA-related activities because of its ability to alter DNA supercoiling. In mammalian cells, Topo II consists of two isozymes, Topo II-alpha (170kDa) and Topo II-beta (180kDa) and expression and localization of each isoform are distinct and stage specific during the cell cycle. Topo II-beta is expressed constitutively throughout the cell cycle, whereas the expression of Topo II-alpha is cell cycle-regulated, peaking in G2 to M phase and declining to a minimal level at the end of M phase. DNA-topoisomerase II is the target of some of the most active drugs used in chemotherapy and has been shown to have a critical role in neural development.

Supplier: Enzo Life Sciences

The Rab family of GTP-binding proteins are members of the Ras superfamily of small G proteins, and participate in multiple steps of the membrane trafficking. Rab3A participates in the fusion of synaptic vesicles during neurotransmitter release, a process regulated by GDP/GDP exchange cofactors such as GAP, GDI, GRF, and rabphilin. Rab4 regulates recycling of proteins from the early endosome to the surface of many cell types, regulating glucose transporter and transferrin receptor cell surface localization. Rab5 regulates the fusion of plasma membrane-derived clathrin-coated vesicles with early endosomes and homotypic fusion among early endosomes.