DMOG is a cell permeable prolyl-4-hydroxylase inhibitor which upregulates HIF activity. HIF activation stimulates angiogenesis in several different models. DMOG also inhibits FIH (Factor Inhibiting HIF), an asparaginyl hydroxylase, which enhances the HIF response. It is active in vivo and attenuates myocardial injury in a rabbit ischemia reperfusion model (20mg/kg). Is expected to act pro-angiogenic.

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EQ0 NHS ester Amin-reaktiver Quencher-Farbstoff

Supplier: ENZO LIFE SCIENCES

Amine-reactive quencher dye has a broad visible absorption but no detectable fluorescence emission in fluorescence resonance energy transfer (FRET) applications.

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FCCP ≥98% (durch TLC)

Supplier: ENZO LIFE SCIENCES

MPTP inhibitor

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VEGFR-2 Substrate (Biotin)

Supplier: ENZO LIFE SCIENCES

This peptide, Biotin-Ahx-EEEEAYGWLDF, is derived from gastrin and can be used as a substrate for KDR/VEGFR2.

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6-(Benzyloxy)-7H-purin-2-amin ≥98% (durch TLC)

Supplier: ENZO LIFE SCIENCES

DNA alkyltransferase substrate and inhibitor

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HPV type 31/33/51 probe, PATHO-GENE®

Supplier: ENZO LIFE SCIENCES

The PATHO-GENE® HPV type 6/11 probe is a mixture of biotin-labeled HPV 6 and HPV 11-specific probes in buffered formamide and hybridisation enhancers.

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Pentoxifylline ≥99%

Supplier: ENZO LIFE SCIENCES

PDE inhibitor

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Trequinsin hydrochloride ≥98% (durch HPLC)

Supplier: ENZO LIFE SCIENCES

Ultrapotent, highly selective inhibitor of cGMP-inhibited phosphodiesterase (PDE lll, IC50=0.3nM) in vitro. Potentiates adenosine-stimulated cAMP accumulation.

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Ras inhibitory peptide

Supplier: ENZO LIFE SCIENCES

The peptide sequence corresponds to amino acid residues 1149-1158 of the guanine nucleotide-releasing factor hSos1, which is essential for the control of Ras activity. Blocks the binding of hSos1 to human Grb2, a protein that binds to activated receptor tyrosine kinases.

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Gelbes IHC-Chromogen (HRP), HIGHDEF®

Supplier: ENZO LIFE SCIENCES

Das gelbe IHC-Chromogen (HRP) ist für die Verwendung in Meerrettichperoxidase(HRP)-basierten Immunfärbe- oder In-situ-Hybridisierungssystemen vorgesehen.

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Matrix Metalloproteinase-2 (MMP-2) Fluorometrisches Wirkstoffentdeckungs-Kit

Supplier: ENZO LIFE SCIENCES

Ein QuantiZyme™ Assay System. Das MMP-2 Fluorometrisches (auch bekannt als fluorimetrisch) Wirkstoffentdeckungs-Kit ist ein vollständiges Assay-System, das zum Screening von Inhibitoren der Matrix-Metalloproteinase-2 (MMP-2, Stromelysin-1) unter Verwendung eines gequenchten, fluorogenen Peptids entwickelt wurde: Fluorogenes OmniMMP™-Substrat Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH. Die Mca-Fluoreszenz wird durch die Dpa-Gruppe gequencht, bis die Spaltung durch MMPs an der Gly-Leu-Bindung die zwei Einheiten trennt. Die Assays werden in einem praktischen Mikroplattenformat mit 96 Wells durchgeführt. Das Kit ist nützlich, um Inhibitoren von MMP-2, einem potenziellen therapeutischen Ziel, zu screenen.

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AMPIGENE® qPCR 1-Step Probe Kit No-ROX

Supplier: ENZO LIFE SCIENCES

Optimised and efficient cDNA synthesis and probe-based qPCR in a single tube.

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KillerTRAIL™ Aufbewahrungs- und Verdünnungspuffer, Enzo Life Sciences

Supplier: Enzo Life Sciences

Aufbewahrungs- und Verdünnungspuffer zur Verwendung mit folgenden Produkten: KillerTRAIL™, Löslich (human) (rekombinant) (Prod. Nr. ALX-201-073)
SuperKillerTRAIL™, Löslich (human) (rekombinant) (Prod. Nr. ALX-201-115)
SuperKillerTRAIL™, Löslich (Maus) (rekombinant) (Prod. Nr. ALX-201-130)
Nützlich zum Vorverdünnen der oben genannten Produkte vor der Vorbereitung von Aliquots, oder der Durchführung von Experimenten. Die Vorverdünnung mit KillerTRAIL™ Lagerungs- und Verdünnungspuffer ermöglicht eine einfachere Handhabung kleiner Arbeitskonzentrationen (manchmal sind nur 0,1 µl der KillerTRAIL™- oder SuperKillerTRAIL™-Stammlösung aufgrund ihrer hohen Aktivität erforderlich). Die Vorverdünnung mit KillerTRAIL™ Lagerungs- und Verdünnungspuffer anstelle von Medium oder PBS verhindert den Verlust der biologischen Aktivität. Kann auch als Negativkontrolle verwendet werden. Kann auch zur Negativkontrolle verwendet werden.

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Fluor-de-Lys® Developer I concentrate

Supplier: Enzo Life Sciences

FLUOR DE LYS® Developer is an essential reagent for signal generation in HDAC or sirtuin assays done with the FLUOR DE LYS® substrate. An appropriate FLUOR DE LYS® family substrate, comprising an acetylated lysine side chain, is first incubated with a sample containing HDAC activity (nuclear or cellular extract, purified enzyme, bead-bound immunocomplex, etc.). Deacetylation of the substrate sensitizes it so that, in a second step, treatment with the FLUOR DE LYS® Developer produces a fluorophore. Typically, an ‘inhibitor stop’ will be included in the 1x Developer dilution (e.g. Trichostatin A) for class I and II HDACs, nicotinamide for sirtuins).

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MK-2206 dihydrochloride ≥99% (durch HPLC)

Supplier: Enzo Life Sciences

Highly selective inhibitor of Akt1, Akt2 and Akt3

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Nodularin

Supplier: Enzo Life Sciences

Inhibitor of PP1 and PP2A

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Sulindac Sulphide ≥99% (durch TLC)

Supplier: Enzo Life Sciences

Active metabolite of sulindac. Inhibits cyclooxygenase. More selective for PGHS-1 (ID50=0.5 µM) over PGHS-2 (ID50=14 µM). Induces apoptosis by a cyclooxygenase-independent mechanism. Inhibits colorectal cancer growth and γ-secretase. NF-κB inhibitor. Inhibits Ras signaling.

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Hematopoietic library, Screen-Well®

Supplier: Enzo Life Sciences

The Screen-Well® hematopoietic toxicity library is a focused collection of 115 compounds with defined and diverse hematopoietic toxicity, including myelosuppression, neutropenia, leukopenia, anaemia, and many more. A variety of structurally and mechanistically different compound classes are included, as well as nontoxic controls. The compounds are dissolved in DMSO at 10 mM and aliquoted into deep-well plates. The library is an essential tool for predictive toxicology screening and assay development.

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Caspase fluorometric substrate set

Supplier: Enzo Life Sciences

Fluorometric substrates for assaying activities of members of caspase family proteases. All substrates are provided in liquid ready-to-use form.

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[(Nepsilon-biotinyl)Lys6]Ubiquitin

Supplier: Enzo Life Sciences

[(Nepsilon-biotinyl)Lys6]Ubiquitin

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Lipid A 1 mg/ml in Wasser (aus E. coli), Serotype R515 (Re) ≥99,9% serotype J5 (Rc), TLRgrade™ anwendungsbereit pyrogenfrei, steril

Supplier: Enzo Life Sciences

TLR4 activator.

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8-Br-cGMP ≥96% (durch HPLC)

Supplier: Enzo Life Sciences

A cell-permeable cGMP analog which is more resistant to phosphodiesterases than cGMP and which preferentially activates cGMP-dependent protein kinase. It inhibits thrombin stimulated arachidonic acid release in human platelets.