Human Recombinant IL-4 (CTGrade GMP) (from E. coli)

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About this item

IL-4 is an immunomodulatory cytokine that stimulates B cell proliferation and activates eosinophils, basophils, and mast cells.

High quality
Low endotoxin
Lot-to-lot consistency
Animal free
Manufactured following GMP guidelines

Induces vascular cell adhesion molecule (VCAM)-1 expression on endothelial cells and involved in collagen production by fibroblasts
Plays a key role in promotion of Th2 differentiation from naive helper T cells
Defines the Th2 phenotype of lymphocytes
Regulates cell proliferation, apoptosis, and expression of numerous genes in various cell types
The biological activity of CTGrade GMP interleukins and growth factors is standardised, where applicable, to WHO International standards, providing cell and gene therapy developers consistent, lot-to-lot biological activity and performance

Host Cell Protein: ≤30 ng/ml
Host Cell DNA: ≤0,01 ng/ml
Sterility testing: No Growth
Mycoplasma: Negative

Caution: For research use or further manufacturing only.

Specifications

Konjugation:
Unconjugated
Protein-Funktion:
Cytokine
Protein/Peptid-Typ:
Rekombinant
Ursprung:
E. coli
Spezies:
Human
Lagerbedingungen:
At or below –20 °C
Endotoxingehalt:
Endotoxin LAL (EU/µg) ≤0,05
Biologische Aktivität:
Bioactivity Assay: TF-1 cell proliferation, ED₅₀ ≤0,25 ng/ml, Bioactivity ≥1,4x10⁴ IU/µg
Gen-ID:
P05112
Reconstitution instructions:
Sterile water at 0,1 - 0,5 mg/ml
Frei von Endotoxinen:
N
Frei von Trägern:
Y
Frei von Proteasen:
N
Tierfrei:
Y
Proteinsynonym:
BCGF|B-cell stimulatory factor-1|BCDF|BSF-1
Protein/Peptid-Name:
CTGrade GMP IL-4
Purity:
≥98%
Molecular weight:
15,1 kDa
Sequence:
MHKCDITLQE IIKTLNSLTE QKTLCTELTV TDIFAASKNT TEKETFCRAA TVLRQFYSHH EKDTRCLGAT AQQFHRHKQL IRFLKRLDRN LWGLAGLNSC PVKEANQSTL ENFLERLKTI MREKYSKCSS
Endotoxinspiegel:
Low
Zusammensetzung:
20 mM Sodium phosphate, pH 7,5
Frei von Nukleasen:
N
Sorte:
GMP
Transporttemperatur:
Ambient
Validierte Anwendungen:
Bioassay