Specifications
- Antikörper-Typ:Primär
- Antigen-Name:Claudin 1
- Klonalität:Polyklonal
- Konjugation:FITC (Fluorescein Isothiocyanate)
- Durchflusszytometrie:Yes
- Wirt:Rabbit
- ImmunoChemie:Yes
- ImmunFluoreszenz:Yes
- Isotyp:IgG
- Reaktivität:Human,Rat,Mouse
- Western blot:Yes
- Epitop:121-211/211
- Form:Liquid
- Gen-ID:12737
- Antigen-Synonyme:Cldn1|AI596271|Claudin-1
- Modification:Unmodified
- Lagerungspuffer:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Molecular weight:23 kDa
- Lagertemperatur:Store at –20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Konzentration:1 µg/µl
- Transporttemperatur:4 °C
- Immunogen:KLH conjugated synthetic peptide derived from mouse Claudin 1
- Validierte Anwendungen:ICC
- Reinigung:Purified by Protein A
- Packung:Vial
- VE:100 µl
Specifications
About this item
Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions.
Type: Primary
Antigen: Claudin 1
Clonality: Polyclonal
Clone:
Conjugation: FITC
Public Immunogen Range: 121-211/211
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat