Specifications
- Antikörper-Typ:Primär
- Antigen-Name:CASC3
- Klonalität:Polyklonal
- Konjugation:Alexa Fluor® 680
- Wirt:Rabbit
- ImmunoChemie:Yes
- ImmunFluoreszenz:Yes
- Isotyp:IgG
- Reaktivität:Mouse
- Western blot:Yes
- Epitop:501-600/703
- Form:Liquid
- Gen-ID:22794
- Antigen-Synonyme:MLN51|Protein barentsz|MLN 51 protein|Btz|Protein CASC3|Protein MLN 51|CASC3_HUMAN|Metastatic lymph node protein 51|Barentsz protein|Cancer susceptibility candidate gene 3 protein
- Modification:Unmodified
- Lagerungspuffer:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Molecular weight:76 kDa
- Lagertemperatur:Store at −20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Konzentration:1 µg/µl
- Transporttemperatur:4 °C
- Immunogen:KLH conjugated synthetic peptide derived from human CASC3/MLN51
- Validierte Anwendungen:ICC
- Reinigung:Purified by Protein A
- Packung:Vial
- VE:100 µl
Specifications
About this item
The multiprotein exon junction complex (EJC) is deposited on mRNAs upstream of exonexon junctions as a consequence of pre-mRNA splicing. In mammalian cells, this complex serves as a key modulator of spliced mRNA metabolism. MLN51 is a nucleocytoplasmic shuttling protein that is overexpressed in breast cancer. The function of MLN51 in mammals remains elusive. Its fly homolog, named barentsz, as well as the proteins mago nashi and tsunagi have been shown to be required for proper oskar mRNA localization to the posterior pole of the oocyte. Magoh and Y14, the human homologs of mago nashi and tsunagi, are core components of the exon junction complex (EJC). The EJC is assembled on spliced mRNAs and plays important roles in post-splicing events including mRNA export, nonsense-mediated mRNA decay, and translation. Human MLN51 is an RNA-binding protein present in ribonucleo-protein complexes.
Type: Primary
Antigen: CASC3
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 680
Public Immunogen Range: 501-600/703
Host: Rabbit
Isotype: IgG
Reactivity: Mouse