- Antikörper-Typ:Primär
- Antigen-Name:SIGLEC10
- Klonalität:Polyklonal
- Konjugation:Alexa Fluor® 680
- Wirt:Rabbit
- Isotyp:IgG
- Reaktivität:Human,Rat,Mouse
- Western blot:Yes
- Epitop:321-420/697
- Form:Liquid
- Gen-ID:89790
- Antigen-Synonyme:sialic acid binding Ig like lectin 10 Ig like lectin 7|Siglecg|Sialic acid binding Immunoglobulin like lectin 10|Siglec G|Siglec like protein 2|siglec like gene 2|PRO940|SLG2|sialic acid binding Ig like lectin G|Sialic acid binding Ig like lectin 10|mSiglec G|SIGLEC 10
- Modification:Unmodified
- Lagerungspuffer:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Molecular weight:77 kDa
- Lagertemperatur:Store at −20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Konzentration:1 µg/µl
- Transporttemperatur:4 °C
- Immunogen:KLH conjugated synthetic peptide derived from human SIGLEC10
- Reinigung:Purified by Protein A
- Packung:Vial
- VE:100 µl
SIGLEC10 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. It preferentially binds to alpha2,3- or 2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. SIGLEC10 interacts with PTPN6/SHP-1 upon phosphorylation. The protein is expressed by peripheral blood leukocytes (eosinophils, monocytes and a natural killer cell subpopulation).
Type: Primary
Antigen: SIGLEC10
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 680
Public Immunogen Range: 321-420/697
Host: Rabbit
Isotype: IgG
Reactivity: Human; Mouse; Rat