- Antikörper-Typ:Primär
- Antigen-Name:Dynamin 1
- Klonalität:Polyklonal
- Konjugation:Alexa Fluor® 680
- Wirt:Rabbit
- ImmunoChemie:Yes
- ImmunFluoreszenz:Yes
- Isotyp:IgG
- Western blot:Yes
- Epitop:551-680/864
- Form:Liquid
- Gen-ID:1759
- Antigen-Synonyme:DYN1_HUMAN|DNM1|Dynamin-1|B dynamin|DNM|DNM 1|Dynamin|Dynamin1|D100
- Modification:Unmodified
- Lagerungspuffer:Aqueous buffered solution containing 0,01M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol.
- Molecular weight:97 kDa
- Lagertemperatur:Store at −20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Konzentration:1 µg/µl
- Transporttemperatur:4 °C
- Immunogen:KLH conjugated synthetic peptide derived from human Dynamin 1
- Validierte Anwendungen:ICC
- Reinigung:Purified by Protein A
- Packung:Vial
- VE:100 µl
Dynamin I is a GTPase enzyme required for the retrieval of synaptic vesicles after exocytosis and functions in endocytosis by stimulating assembly of invaginating synaptic vesicles (1). Dynamin I is phosphorylated in nerve terminals exclusively in the cytosolic compartment and in vitro by protein kinase C (PKC) (25). The phosphorylation site in PKC-phosphorylated Dynamin I is a single site at Serine 795, which is located near a binding site for the SH3 domain of p85, the regulatory subunit of phosphatidylinositol 3-kinase (25). Dephosphorylation is required for synaptic vesicle retrieval, suggesting that phosphorylation affects the subcellular localization of Dynamin I (5). Mouse, rat and human Dynamin I are phosphorylated on serine residues, including Ser 778, by Cdk5, regulating PACSIN1 recruitment and enabling synaptic vesicle endocytosis.
Type: Primary
Antigen: Dynamin 1
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 680
Public Immunogen Range: 551-680/864
Host: Rabbit
Isotype: IgG
Reactivity: