Human recombinant BDNF (from E. coli)

Über diesen Artikel

Brain-derived neurotrophic factor (BDNF) is a nerve growth factor that binds two receptors, the low-affinity nerve growth factor receptor (LNGFR) and the tropomyosin receptor kinase B (TrkB), to support neuron growth and survival.

Animal-free
Produced from genetically modified E. coli
Noncovalent homodimeric protein, containing 120/240 amino acids

BDNF expression in the hippocampus is essential for long-term memory storage and learning. Human, mouse, rat, and pig BDNF are cross-reactive.

Delivery: A certificate of analysis (COA) is supplied with each product shipped detailing purity, formulation, biological activity, endotoxin levels, reconstitution instructions and recommended storage conditions.

Caution: This product is for research use only and is not for use in humans.

Spezifikationen

Konjugation:
Unconjugated
Protein-Funktion:
Cytokine
Protein/Peptid-Typ:
Rekombinant
Ursprung:
E. coli
Spezies:
Human
Lagerbedingungen:
–20 °C
Endotoxingehalt:
Endotoxin LAL (EU/µg) ≤0,1
Biologische Aktivität:
Bioactivity assay: Proliferation of a neuroblastoma cell line stably expressing TrkB (BR6), ED50 ≤40 ng/ml, Bioactivity ≥2,5×10⁴ units/mg
Form:
Lyophilised
Gen-ID:
P23560
Reconstitution instructions:
Sterile water at 0.1 mg/ml
Frei von Endotoxinen:
N
Frei von Trägern:
Y
Frei von Proteasen:
N
Tierfrei:
Y
Proteinsynonym:
ANON2|brain-derived neurotrophic factor|BNDF|brain derived neurotrophic factor|BULN2
Protein/Peptid-Name:
BDNF
Purity:
≥95%
Molecular weight:
13,6/27,3 kDa
Sequence:
MHSDPARRGE LSVCDSISEW VTAADKKTAV DMSGGTVTVL EKVPVSKGQL KQYFYETKCN PMGYTKEGCR GIDKRHWNSQ CRTTQSYVRA LTMDSKKRIG WRFIRIDTSC VCTLTIKRGR
Endotoxinspiegel:
Low
Zusammensetzung:
0,1% Trifluoroacetic Acid (TFA)
Frei von Nukleasen:
N
Sorte:
RUO
Transporttemperatur:
RT
Validierte Anwendungen:
Bioassay