About this item
Interleukin 17AF (IL-17AF) is a heterodimer that is composed of the interleukin 17A (IL-17A) and interleukin 17F (IL-17F) members of the IL-17 family of cytokines. IL-17AF is produced by T helper 17 cells (Th17) following interleukin 23 (IL-23) stimulation.
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IL-17AF signals through the IL-17RA/IL-17RC receptor complex and functions to regulate inflammatory responses. IL-17AF induces chemokine and airway neutrophilia production, similar in function to IL-17A and IL-17F homodimers. In regard to these functions, IL-17AF is less active than the IL-17A homodimer and shows greater activity than the IL-17F homodimer. Human and rat IL-17AF are active on mouse cells.
This functions as a mitogenic growth hormone on cells of mesenchymal lineage, such as smooth muscle and glial cells. It is also stored in the alpha-granules of platelets and is released upon adherence to traumatized tissues.
This dimeric glycoprotein formed by two A chains (AA), two B chains (BB), or as a heterodimer with an A and a B chain (AB).
Specifications
- Konjugation:Unconjugated
- Protein-Funktion:Cytokine
- Protein/Peptid-Typ:Rekombinant
- Ursprung:E. coli
- Spezies:Mouse
- Lagerbedingungen:−20 °C
- Endotoxingehalt:Endotoxin LAL (EU/µg) ≤1
- Biologische Aktivität:Bioactivity assay: 3T3 cell proliferation, ED50 ≤2 ng/ml, bioactivity ≥5,0×10⁵ units/mg
- Gen-ID:P31240
- Reconstitution instructions:Sterile water at 0,1 mg/ml
- Frei von Endotoxinen:N
- Frei von Trägern:Y
- Frei von Proteasen:N
- Tierfrei:N
- Proteinsynonym:ODGF|GDGF
- UniProtKB:P31240
- Protein/Peptid-Name:PDGF-BB
- Purity:≥95%
- Molecular weight:12,4/24,7 kDa
- Sequence:MSLGSLAAAE PAVIAECKTR TEVFQISRNL IDRTNANFLV WPPCVEVQRC SGCCNNRNVQ CRASQVQMRP VQVRKIEIVR KKPIFKKATV TLEDHLACKC ETIVTPRPVT
- Endotoxinspiegel:Low
- Zusammensetzung:10 mM sodium citrate, pH 3,0
- Frei von Nukleasen:N
- Sorte:RUO
- Transporttemperatur:RT
- Validierte Anwendungen:Bioassay