Specifications

VE:
50 µG
Protein/Peptid-Typ:
Rekombinant
Ursprung:
CHO cells
Spezies:
Rat
Tag sequence:
Fc Tag
Lagerbedingungen:
Stable for at least 1 year after receipt when stored at −20 °C. Working aliquots are stable for up to 3 months when stored at −20 °C.
Proteinsynonym:
High Mobility Group Protein B1
Protein/Peptid-Name:
HMGB1
Purity:
>98% (SDS-PAGE)
Sequence:
24-215
Zusammensetzung:
Lyophilized from 0.2um-filtered solution in PBS.

Specifications

About this item

HMGB1 was originally discovered as an essential DNA-binding protein for regulating p53, NF-kappaB and other important proteins. It is secreted from activated dentric cells, macrophage and nectrotic cells, and acts as a ligand for RAGE, TLR-2 and TLR-4 expressed on surrounding cells. As a result, HMGB1 activates Rac, CDC42 and NF-kappaB inducing localised innate immunity of damaged tissue, tissue regeneration by recruitment of stem cells and hemostasis by induction of tissue factor expression. HMGB1 is also causative agent of various diseases as it causes localised inflammation such as arteriosclerosis, chronic rheumatoid arthritis and nephritis.

Fusion-Tag: Fc Tag

This recombinant proteins is for research use only.