- VE:50 µG
- Protein/Peptid-Typ:Rekombinant
- Ursprung:E. coli
- Tag sequence:His Tag
- Lagerbedingungen:Stable for at least 6 months after receipt when stored at −80 °C.
- Biologische Aktivität:Specific activity towards L-Trp: 87.0umol/hr per mg. TDO catalyzes the oxidative opening of the L-tryptophan indole moiety to yield N-formylkynurenine (NFK).
- Proteinsynonym:TRPO|Tryptophan Oxygenase|Tryptophan 2,3-dioxygenase|TPH2|Tryptophan Pyrrolase|Tryptophanase
- Protein/Peptid-Name:TDO Anopheles gambiae
- Purity:>98% (SDS-PAGE)
- Zusammensetzung:Liquid, In 50mM sodium phosphate pH 8.0, containing 0.15M sodium chloride, 0.2M imidazole and 10% glycerol.
Tryptophan 2,3-dioxygenase (TDO) is a heme-containing dioxygenase catalyzing the addition of molecular oxygen across the 2,3-double bond of the indole ring of tryptophan to form N-formylkynurenine (NFK). In Anopheles gambiae, TDO is the only enzyme able to catalyze the first and rate-limiting step in L-Trp catabolism through the kynurenine pathway. Tryptophan is an essential amino acid for protein synthesis and also the precursor for production of a number of neurotransmitters, such as serotonin and melatonin; in mosquitoes, the kynurenine pathway is essential for eye pigmentation. Conceivably, the tryptophan-using pathways should be regulated in a coordinated manner in mosquitoes as well as in other species and TDO activation/inactivation processes could play an essential role in these phenomena.
Fusion-Tag: His Tag
This recombinant proteins is for research use only.