Human recombinant SHMT1 (from cells)
PRSI91-687
:
- VE:50 µG
- Protein/Peptid-Typ:Rekombinant
- Ursprung:Cells
- Spezies:Human
- Tag sequence:C-6 His tag
- Lagerbedingungen:Lyophilized protein should be stored at −20 °C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 °C for 2-7 days. Aliquots of reconstituted samples are stable at −20 °C for 3 months.
- Proteinsynonym:Serine Hydroxymethyltransferase Cytosolic|Serine Methylase|SHMT1|SHMT|Glycine Hydroxymethyltransferase
- Protein/Peptid-Name:SHMT1
- Purity:> 95% as determined by reducing SDS-PAGE
- Molecular weight:53.9 kD
- Sequence:Met3-Phe483
- Zusammensetzung:Lyophilized from a 0.2 um filtered solution of 20mM PB,150mM NaCl,pH7.4. Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the Lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
- Validierte Anwendungen:Bioassay
Serine Hydroxymethyltransferase Cytosolic (SHMT1) is a member of the SHMT family. SHMT1 is a cytoplasmic protein and exists as a homotetramer. SHMT1 catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one carbon unit for the synthesis of methionine, thymidylate, and purines in the cytoplasm. A reduction in SHMT1 levels would result in less glycine that could affect the nervous system by acting as an agonist to the NMDA receptor and this could be a mechanism behind Smith-Magenis syndrome.
- This recombinant protein can be used for biological assays. For research use only.
Fusion-Tag: C-6 His tag