- VE:50 µG
- Protein/Peptid-Typ:Rekombinant
- Ursprung:Cells
- Spezies:Human
- Tag sequence:C-6 His tag
- Lagerbedingungen:Lyophilized protein should be stored at −20 °C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 °C for 2-7 days. Aliquots of reconstituted samples are stable at −20 °C for 3 months.
- Proteinsynonym:IL-17|IL17|CTLA8|IL17A|IL-17A|Cytotoxic T-Lymphocyte-Associated Antigen 8|CTLA-8|Interleukin-17A
- Protein/Peptid-Name:IL17
- Purity:> 95% as determined by reducing SDS-PAGE
- Molecular weight:20.5 kD
- Sequence:Gly24-Ala155
- Zusammensetzung:Lyophilized from a 0.2 um filtered solution of 20mM PB,150mM NaCl,pH7.4. Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the Lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
- Validierte Anwendungen:Bioassay
Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. As IL-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumatoid arthritis synovium. It increases IL-6 production, induces collagen degradation and decreases collagen synthesis by synovium and cartilage and proteoglycan synthesis in cartilage. IL-17 is also able to increase bone destruction and reduce its formation. Blocking of interleukin-17 with specific inhibitors provides a protective inhibition of cartilage and bone degradation.
- This recombinant protein can be used for biological assays. For research use only.
Fusion-Tag: C-6 His tag