Specifications
- Antikörper-Typ:Kontrolle
- Antigen-Name:TGF-Beta Activated Kinase 3
- Antigen-Symbol:TAB3
- Klonalität:Polyklonal
- Konjugation:Unconjugated
- ELISA:Yes
- Wirt:Rabbit
- ImmunoChemie:Yes
- Isotyp:IgG
- Reaktivität:Human
- Western blot:Yes
- Antigen-Synonyme:MAP3K7IP3|TAB3|NAP1|Mitogen-activated protein kinase kinase kinase 7-interacting protein 3|TGF-beta-activated kinase 1 and MAP3K7-binding protein 3|TAB-3
- Lagerungspuffer:PBS containing 0.02% sodium azide
- Immunogen:TAB3 antibody was raised against a 13 amino acid synthetic peptide near the amino terminus of human TAB3.
- Validierte Anwendungen:E, IHC
- Reinigung:Affinity chromatography purified via peptide column
- Größe:100 µg
- VE:100 µG
Specifications
About this item
TAB3 Antibody: TAB3 functions in the NF-kappaB signal transduction pathway. It and the similar and functionally redundant protein TAB2, form a ternary complex with the protein kinase TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. Recent experiments have shown that TAB2 and the related protein TAB3 constitutitvely interact with the autophagy mediator Beclin-1; upon induction of autophagy, these proteins dissociate from Beclin-1 and bind TAK1. Overexpression of TAB2 and TAB3 inhibit autophagy, while their depletion triggers it, suggesting that TAB2 and TAB3 act as a control point for autophagy.
Type: Control
Antigen: TAB3
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human