- Antikörper-Typ:Primär
- Antigen-Name:Cleavage Stimulation Factor, 3' pre-RNA, Subunit 3, 77kDa
- Antigen-Symbol:CSTF3
- Klonalität:Polyklonal
- Konjugation:Alexa Fluor® 488
- Wirt:Rabbit
- ImmunoChemie:Yes
- Isotyp:IgG
- Reaktivität:Human,Rat,Mouse
- Kreuzadsorption:No
- Form:liquid
- Gen-ID:1479
- Antigen-Synonyme:MGC75122|CSTF 77 kDa subunit|MGC117398|cleavage stimulation factor 3' pre-RNA subunit 3 77kDa|cleavage stimulation factor subunit 3 isoform 1|cleavage stimulation factor subunit 3|MGC43001|CSTF-77
- Lagerungspuffer:Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
- Lagertemperatur:Store at 4°C for 12 months
- Konzentration:1 μg/μl
- Transporttemperatur:4°C
- Reinigung:Purified by Protein A
- VE:100 µl
Polyadenylation of mRNA precursors is a two-step reaction that requires multiple protein factors. The first step, endonucleolytic cleavage of polyadenylation substrates, requires CstF (cleavage stimulation factor), a heterotrimer that is composed of three distinct subunits. Heterotrimeric CstF recognizes GU- and U-rich sequences located downstream of the polyadenylation site on RNA. CstF-77 (cleavage stimulation factor, 77 kDa subunit), also known as CstF3, is one of the three subunits comprising CstF. It can exist as a homodimer and functions as the bridge, directly interacting with the other two CstF subunits, namely CstF-64 and CstF-50. CstF-77 is highly conserved among eukaryotes. It contains an Alpha-helical structure with 11 HAT (Half-a-TPR-containing) repeats and is essential for CstF assembly. In addition, CstF-77 is capable of interacting with CPSF1 and FCP1, other factors involved in polyadenylation.
Recommended Dilutions: IF(IHC-P): 1:50-200
Type: Primary
Antigen: CSTF3
Clonality: Polyclonal
Clone:
Conjugation: Alexa Fluor® 488
Epitope:
Host: Rabbit
Isotype:
Reactivity: