- Antikörper-Typ:Primär
- Antigen-Name:Sialic acid binding Ig-like lectin 10
- Antigen-Symbol:SIGLEC10
- Klonalität:Polyklonal
- Konjugation:Unconjugated
- Durchflusszytometrie:Yes
- Wirt:Rabbit
- ImmunoChemie:Yes
- Isotyp:IgG
- Reaktivität:Human,Rat,Mouse
- Western blot:Yes
- Form:liquid
- Antigen-Synonyme:PRO940|SLG2|SIGLEC-10
- Lagerungspuffer:Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0,09% sodium azide. Store at -20°C for 12 months.
- Konzentration:1 ug/ul
- Transporttemperatur:4 °C
- Reinigung:Purified by Protein A.
- Größe:100 μg
- VE:100 µl
SIGLEC10 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. It preferentially binds to alpha2,3- or 2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. SIGLEC10 interacts with PTPN6/SHP-1 upon phosphorylation. The protein is expressed by peripheral blood leukocytes (eosinophils, monocytes and a natural killer cell subpopulation).
WB(1:100-1000), FCM(1:20-100), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
Type: Primary
Antigen: SIGLEC10
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat