You searched for: Proteine und Peptide

Supplier: ACROBIOSYSTEMS

Human recombinant integrin alpha 4 beta 7 (from HEK293)

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Human recombinant CEACAM-5 (from HEK293), Acro Biosystems

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Human recombinant Tau-441 (from E. coli)

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Human recombinant IL-6 R alpha (from HEK293)

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Human recombinant NTB-A (from HEK293)

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Mouse recombinant CD27 Ligand (from HEK293)

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Human recombinant integrin alpha V beta 5 (from HEK293)

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Mouse recombinant Glypican 2 (from HEK293 cells)

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Human recombinant TROP-2 (from HEK293 cells)

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Mouse Properdin protein, His Tag.

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Cynomolgus monkey recombinant IL-31 (from HEK293 cells)

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Cynomolgus monkey recombinant Siglec-10 (from HEK293 cells)

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Human recombinant Her2 (from HEK293 cells)

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Human recombinant CD73 (from HEK293 cells)

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Human recombinant GUCY2C (from HEK293 cells), biotin

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Mouse recombinant Fc gamma RIII/ CD16 (from HEK293 cells)

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Human recombinant Glypican 2 (from HEK293 cells)

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Mouse recombinant BAFF (from HEK293)

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Mouse recombinant neuropilin-1 (from HEK293)

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Human recombinant M-CSF (from HEK293)

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Mouse recombinant VEGF R1 (from HEK293)

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Human recombinant LILRB3 (from HEK293)

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Human recombinant LILRB2 (from HEK293)

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Human recombinant B7-H5 (from HEK293)

Supplier: STEMCELL Technologies

Myostatin is a member of transforming growth factor beta (TGF-β) superfamily that signals by binding to activin type II receptor, resulting in the recruitment of either ALK3 or ALK4 coreceptor, and activation of SMAD2/3 (Kondás et al.). It is released by myocytes and inhibits muscle growth and ability to regenerate (Lee and Lee). Myostatin appears to affect the lipid catabolic metabolism of adipocytes and inhibits preadipocyte differentiation, as demonstrated in the 3T3-L1 cell line (Li et al.).

Supplier: STEMCELL Technologies

Tumor necrosis factor-beta (TNF-β), also known as lymphotoxin-alpha, is a member of the TNF family. It is a pro-inflammatory cytokine that activates NF-kB, MAPK, and PI3K/AKT pathways upon binding to TNF receptors 1 and 2. It is produced mainly by T cells, though other cells can express TNF-β at lower levels (Chu). TNF-β is involved in autoimmune disorders, lymph node development, and mediating the inflammatory demyelination process (Seleznik et al.; McCarthy et al.).

Supplier: STEMCELL Technologies

Stimulating T cells with CMV (HLA Class I Control) Peptide pool releases downstream cytokines and upregulates activation markers, enabling antigen-specific T cells to be detected or isolated for analysis. CMV Peptide pool is a lyophilised mixture of 14 peptides from the human cytomegalovirus (CMV) and consists of defined HLA class I-restricted T cell epitopes. Viral peptide pools are useful for a broad range of applications, including vaccine development, immunological research, and diagnostic assay development. For consistency and reproducibility across your applications, CMV Peptide pools from STEMCELL are formulated as lyophilised trifluoroacetate salts, with a purity ≥95%.

Supplier: STEMCELL Technologies

Human (Actin) peptide pool is a lyophilised mixture of 92 peptides from human actin, alpha skeletal muscle, and consists of 15-mer peptides with 11-amino-acid overlaps that cover amino acids 1 to 377 on actin. It is frequently used as a negative control. Actin, alpha skeletal muscle, is part of the highly conserved actin protein family and is the predominant isoform found in adult skeletal muscle (Laing et al.). Peptide pools are useful for a broad range of applications, including vaccine development, immunological research, and diagnostic assay development.

Supplier: STEMCELL Technologies

Interleukin 6 (IL-6) is a pleiotropic growth factor with the wide range of biological activities in immune regulation, hematopoiesis, and oncogenesis. IL-6 is produced by a variety of cell types including T cells, B cells, monocytes and macrophages, fibroblasts, hepatocytes, vascular endothelial cells, and various tumor cell lines. On its own or in combination with other factors such as IL-2 and interferon-γ, IL-6 stimulates the proliferation of B cells, T cells, and hybridoma cells (Hirano et al.; Mihara et al.; Tanaka et al). In combination with cytokines such as IL-3, GM-CSF and SCF, IL-6 has been shown to promote hematopoietic progenitor cell proliferation and differentiation in vitro. IL-6 signals through a cell surface type I cytokine receptor complex consisting of the ligand-binding IL-6α (CD126) and the signal-transducing gp130 subunits. The binding of IL-6 to its receptor system includes activation of JAK/STAT signaling pathway (Mihara et al.; Peters et al.; Tanaka et al.). This product is animal component-free.

Supplier: STEMCELL Technologies

Insulin-like growth factor-binding protein 4 (IGFBP-4) inhibits the actions of IGF-I and IGF-II. The distribution of IGFBP-4 in tissues is dependent on its glycosylation state, however it preferentially targets connective tissue (Firth and Baxter; Qin et al.). IGFBP-4 is also produced in liver, adrenal glands, Leydig cells, developing embryos, spinal cord, and thymic cortex. IGFBP-4 inhibits WNT/β-catenin signaling, which downregulates prostate cancer proliferation (Zhu et al.). In vitro studies suggest that IGFBP-4 inhibits proliferation of neuroblastoma and glioma, while promoting bone loss in osteosarcoma and multiple myeloma (Durai et al.).